Results 61 to 70 of about 3,436,251 (315)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Navigating Disputes Beyond Earth: A Critical Analysis of the PCA Outer Space Rules
The rapid commercialization of outer space, including satellite deployment, space tourism, and asteroid mining, has created an urgent need for effective dispute settlement mechanisms.
Mohammad Owais FAROOQUI +3 more
doaj +1 more source
Prevention of NEO hazard: the Russian approach
Russian Academy of Sciences (RAS) is actively working to solve the problem of preventing Near-Earth Object (NEO) hazard. The article provides the goals and objectives of preventing NEO hazard, as well as ways to achieve them.
Pavlova Elena, Voropaev Viktor
doaj +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
THE INFLUENCE OF ‘GANG BARU’ TRADITIONAL MARKET ACTIVITIES IN THE USE OF PUBLIC SPACE IN SEMARANG CHINATOWN [PDF]
Chinatown is one of the commercial district in Semarang city, which continues to grow in the city center. It’s a 'generator' that drives a wide variety of economic activities, also self-actualization and disclosure of aspiration, expression of the people.
Fiton Dwi, Setiawan, Rina, Kurniati
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Taking Measure of the Universe [PDF]
This is a poster with classroom activities related to NASA’s Space Interferometry Mission. It introduces measurement and scale using hands-on activities.
core
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source

