Results 81 to 90 of about 3,436,251 (315)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Radiation protection for manned space activities [PDF]
The Earth's natural radiation environment poses a hazard to manned space activities directly through biological effects and indirectly through effects on materials and electronics.
Jordan, T. M.
core +1 more source
Public Space: Activation v. De-Activation
New Instrumentalities, 2018 Historically, the great cities of the world have built public spaces that have often been used as venues for spectacle, and displays of power and status. These public venues are part of the identity of these cities and have an importance and influence far beyond their physical dimensions or geometric shapes.
Clifton C. Ellis, David J. Isern
openaire +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
THE COLUMBUS GROUND SEGMENT – A PRECURSOR FOR FUTURE MANNED MISSIONS [PDF]
, 2011 In the beginning the space programs were self standing national activities, often in competition to other nations. Today space flight becomes more and more an international task.
Müller, Thomas
core
IASM: Individualized activity space modeler
SoftwareX, 2018 Researchers from various disciplines have long been interested in analyzing and describing human mobility patterns. Activity space (AS), defined as an area encapsulating daily human mobility and activities, has been at the center of this interest. However, given the applied nature of research in this field and the complexity that advanced geographical ...
openaire +4 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Vulnerability-attention analysis for space-related activities [PDF]
Techniques for representing and analyzing trouble spots in structures and processes are discussed. Identification of vulnerable areas usually depends more on particular and often detailed knowledge than on algorithmic or mathematical procedures.
Ford, Donnie +3 more
core +1 more source
ESA activities in space laser sounding and ranging [PDF]
, 1986 Laser remote sensing from space is undoubtedly one of the most promising means to obtain essential atmospheric and geophysical parameters on a global scale.
Lutz, H.
core +1 more source