Results 101 to 110 of about 701,390 (314)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Role of States in Regulating Space Activities in International Law [PDF]
فصلنامه علوم و فناوری فضایی, 2017 International regulations consist of rights and obligations of states in relation to space. States should respect the international obligations with all of their public and private sectors.
H. Kazemi, Ali Akbar Golro
doaj
European Space Lidar Activities.
The Review of Laser Engineering, 1995 Active laser remote sensing from space is recognised to be one of the most promising newmeans of obtaining essential atmospheric parameters on a global scale. This report gives anoverview on the ESA activities and will focus in the second part on the ongoing Doppler lidarsdevelopment at the German Aerospace Research Establishment (DLR).
openaire +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The future of newman's defensible space theory
, 2011 This paper will highlight the evolution of defensible space theory - from Newman's original theoretical model to some of the subsequent theoretical and empirical developments that have been made in the past 35 years. By charting these developments in our
Elffers, H, Reynald, DM
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Japanese space policy: An international legal perspective
Японские исследованияJapan’s advancements in technology and its strategic focus on space policy have driven swift advancements in the field, attributed to Japan’s ability to balance scientific exploration, industrial growth, and national defense.
A. N. Vylegzhanin +2 more
doaj +1 more source
Review of U.S. Human Space Flight Plans Committee
, 2010 This website contains information about the Review of U.S. Human Space Flight Plans Committee including their final report from October 2009. Acourding to their "About" page, "[t]he "Review of United States Human Space Flight Plans" is to examine ...
United States. National Aeronautics and Space Administration. Review of U.S. Human Space Flight Plans Committee.
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source