Results 91 to 100 of about 3,436,251 (315)

Learning Activity Spaces: Towards Flexibility in Learning Design?

2009 Ninth IEEE International Conference on Advanced Learning Technologies, 2009
Designing a computer-supported learning scenario involving a constructivist approach of learning lays on a paradox. On the one hand, learning flows must be precisely described - including role distribution, required resources, tools, and scaffolds - to be realized in computer-supported environments.
Lejeune, Anne, Ney, Muriel, Weinberger, Armin, Pedastre, Margus, Bollen, Lars, Hovardas, Tasos, Hoppe, Ulrich, de Jong, Ton   +7 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Life-Space Activities Are Associated with the Prognosis of Older Adults with Cardiovascular Disease. [PDF]

J Cardiovasc Dev Dis, 2022
Hashimoto K, Hirashiki A, Oya K, Sugioka J, Tanioku S, Sato K, Ueda I, Itoh N, Kokubo M, Shimizu A, Kagaya H, Kondo I.   +11 more
europepmc   +1 more source

Space life sciences: A status report [PDF]

, 1990
The scientific research and supporting technology development conducted in the Space Life Sciences Program is described. Accomplishments of the past year are highlighted. Plans for future activities are outlined.

core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Artificial Intelligence as an Object of Global Digital Governance [PDF]

Advanced Space Law
The article offers the author’s understanding of the essence of artificial intelligence as a phenomenon of the digital society. The features of artificial intelligence as conditions for the transformation of global digital governance are determined.
Diana Levchenko
doaj   +1 more source

Schedule of French space activities for 1970 [PDF]

Spacecraft launchings, international cooperation, and other French space activities ...

core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Space station group activities habitability module study: A synopsis [PDF]

Space station habitability was studied by investigating crew activity routines, proximities, ergonomic envelopes, and group volumes. Ten alternative schematic interior designs were proposed.
Glassman, Terry, Nixon, David
core   +1 more source