Results 91 to 100 of about 701,390 (314)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Editorial: crime patterns in time and space: the dynamics of crime opportunities in urban areas [PDF]
, 2015 The routine activity approach and associated crime pattern theory emphasise how crime emerges from spatio-temporal routines. In order to understand this crime should be studied in both space and time. However, the bulk of research into crime patterns and
Marcus Felson +6 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Artificial Intelligence as an Object of Global Digital Governance [PDF]
Advanced Space LawThe article offers the author’s understanding of the essence of artificial intelligence as a phenomenon of the digital society. The features of artificial intelligence as conditions for the transformation of global digital governance are determined.
Diana Levchenko
doaj +1 more source
Organising family life: An analysis of the spatial organisation of people and activities in the household [PDF]
, 2019 How Cultural Patterns Are Reflected On Domestic Space Has Been Vastly Discussed In Space Syntax Literature. The Genotype Analogy Was Developed With The Underlying Notion That The Configurational Properties Of Architectural Function Reflect Patterns Of
Varoudis, T +3 more
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Towards an integrated scientific and social case for human space exploration
, 2004 I will argue that an ambitious programme of human space exploration, involving a return to the Moon, and eventually human missions to Mars, will add greatly to human knowledge. Gathering such knowledge is the primary aim of science, but science's compart-
Crawford, Ian
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
, 2020 Professor Bin Cheng is credited with the notion that space law, unlike other legal regimes such as air law, can include elements that arise as “instant” customary international law.
Freeland, Steven R. +3 more
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