Results 111 to 120 of about 701,390 (314)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Activities of the Space Advanced Research Team at the University of Glasgow [PDF]
, 2008 A wide range of technologies and methodologies for space systems engineering are currently being developed at the University of Glasgow. Much of the work is centred on mission analysis and trajectory optimisation, complemented by research activities in ...
Vasile, M., Radice, G.
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, 2019 This article provides a summary on the origins of the concept of the Long-Term Sustainability of Outer Space Activities (LTSOSA) by reviewing previous discussions related to the definition of this concept with the conclusion that the LTSOSA is in fact ...
Yan, Y
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
NASA Technical Exhibit: Space for the Benefit of Mankind, Seattle World's Fair, 1962
, 1962 From the introduction: The National Aeronautics and Space Administration (NASA) is a civilian agency established in 1958 by the Congress of the United States to control and manage the Nation's programs for peaceful aeronautical and space activities ...
National Aeronautics and Space Administration
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An Economic Assessment of Space Solar Power as a Source of Electricity for Space-Based Activities [PDF]
We develop a conceptual model of the economic value of space solar power (SSP) as a source of power to in-space activities, such as spacecraft and space stations.
Davis, James, Macauley, Molly
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
National space law. The case of France ad new challenges for space activities
, 2017 Space activities are risked and the increase level of commercial and private interests in outer space lead States on developing national legal frameworks for space activities, particularly with regard of their responsibilities.
Anne-Sophie Martin
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source