Results 71 to 80 of about 8,796,735 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Activities of the Space Advanced Research Team at the University of Glasgow [PDF]
, 2008 A wide range of technologies and methodologies for space systems engineering are currently being developed at the University of Glasgow. Much of the work is centred on mission analysis and trajectory optimisation, complemented by research activities in ...
Vasile, M., Radice, G.
core +5 more sources
Moon Exploration: Legal Aspects [PDF]
Advanced Space Law, 2019 Legal aspects of the theory and practice of Moon exploration are investigated through the problem statement in philosophical and legal discourse with the reflection of history, current condition and prospects, including the issue of its total ...
Sergey Krichevsky, Alexander Bagrov
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Artificial Intelligence as an Object of Global Digital Governance [PDF]
Advanced Space LawThe article offers the author’s understanding of the essence of artificial intelligence as a phenomenon of the digital society. The features of artificial intelligence as conditions for the transformation of global digital governance are determined.
Diana Levchenko
doaj +1 more source
State Space Agency of Ukraine: History of the Development of Normative Base [PDF]
Advanced Space Law, 2018 Space research is carried out in many countries. However, correct organization of this activity requires proper state regulation. In the paper, the authors reviewed the history of the creation of the normative base of the space agency of Ukraine.
Yulia Iurynets
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Italian Space Agency Space Debris Mitigation Activities - Delegation Report
, 2022 Report to IADC WG-4 of the space debris mitigation activities carried out by ASI since the previous IADC plenary ...
Anselmo L, Vellutini E
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source