Results 161 to 170 of about 7,292 (256)

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan   +11 more
wiley   +1 more source

High-capacity and secure inter-satellite optical wireless communication using 2D DPS-OCDMA. [PDF]

open access: yesSci Rep
Armghan A   +5 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

open access: yesBMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo   +9 more
wiley   +1 more source

Debunking the Myth: A Dive Into the Role of Relational Capital in Sustainable Food Production Systems

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT The shift towards sustainable food production is essential to address the urgent dual challenges of climate change and population growth, with agricultural cooperatives playing a vital role in this transformation. However, many cooperatives struggle to deliver the expected value to their members.
Ismail Badraoui   +4 more
wiley   +1 more source

Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins

open access: yesChemistry – A European Journal, EarlyView.
ABSTRACT The rational design of hybrid nanomaterials with precisely controlled properties remains a central challenge in materials science. While atomically precise gold nanoclusters (Au‐NCs) offer molecule‐like control over a metallic core, tuning their optoelectronic behavior via surface engineering is often empirically driven.
Santiago Rodriguez   +15 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

open access: yesChemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda   +5 more
wiley   +1 more source

A Polarization-Multiplexed Multifunctional Metalens for Triple-Focus Coplanar Imaging. [PDF]

open access: yesNanomaterials (Basel)
Lu H   +6 more
europepmc   +1 more source

Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

open access: yesDroplet, EarlyView.
Droplet microfluidics enables precise, versatile fabrication of hydrogel particles with controlled size, composition, and structure. This review summarizes fundamental principles, engineering strategies, and emerging applications, providing a framework for advancing microfluidic hydrogel technologies.
Zhongqiao Gan, Xu Hou
wiley   +1 more source

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