Results 171 to 180 of about 53,472 (290)

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Fabrication of High‐Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS

Advanced Science, EarlyView.
A chiplet‐based methodology democratizes active neural probe development on standard bulk CMOS services. This yields the first probe combining high‐density electrophysiology (416 electrodes) with calcium imaging (832 photodiodes) and complete on‐chip signal processing across 13 shanks.
Ju Hee Mun, Miji Kim, Wooyeon Shin, Yongjun Park, Kanghwan Kim, Il‐Joo Cho, Jae Won Shim, Min Soo Kim, Sunwoo Lee, Jeongjin Kim, Changhyuk Lee   +10 more
wiley   +1 more source

Time-Division Multiplexing for Parallel Transmission at Ultra-High Field With Limited RF Channels. [PDF]

Magn Reson Med
Glang F, Solomakha GA, Bosch D, Scheffler K, Avdievich NI.   +4 more
europepmc   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Microcomb-enabled parallel self- calibration optical convolution streaming processor. [PDF]

Light Sci Appl
Wang J, Xu X, Zhu X, Xu Y, Chen S, Zhang H, Zheng Y, Li S, Bai Y, Liu Z, Morandotti R, Little BE, Chu ST, Lowery AJ, Moss DJ, Xu K.   +15 more
europepmc   +1 more source

Large‐Aperture Polarization‐Independent Broadband Achromatic All‐Dielectric Metalens for Terahertz Focusing

Advanced Science, EarlyView.
A large‐aperture, high focusing efficiency and polarization‐independent THz single‐layer achromatic metalens is reported via discrete multi‐wavelength achromatic design and global optimization algorithm. The fabricated metalens exhibits a largest diameter of 2.21 cm, excellent achromatic performance, extremely high average focusing efficiency (> 46 ...
Xiaoqiang Jiang, Xu Chen, Zechuan Bin, Fu Tang, Min Hu, Manman Li, Baoli Yao   +6 more
wiley   +1 more source

Robust high-capacity free-space optical communication using OAM-based structured light and intelligent adaptive signal processing. [PDF]

Sci Rep
Ahmad M, Hayat B, Fang M, Wang C, Xie G, Huang Z.   +5 more
europepmc   +1 more source

Enzyme‐Activated MRI for In Vivo Glucose Imaging via a Biodegradable Chromium Nanoprobe

Advanced Science, EarlyView.
Enzyme‐activated MRI (eaMRI) using a biodegradable CrGOx@Lip nanoprobe enables glucose‐specific imaging in vivo. GOx catalyzes glucose oxidation, triggering in situ formation of paramagnetic chromium gluconate and amplifying T1. This radiation‐free strategy maps tumor glucose uptake via the Warburg‐effect, quantifies hepatic glucose accumulation in ...
Yan Xu, Weitao Yang, Yanjing Yun, Hui Wang, Zhuoyao Wu, Youyi Yu, Bingbo Zhang   +6 more
wiley   +1 more source