Results 211 to 220 of about 53,850 (285)

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li   +4 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

open access: yesAngewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach   +4 more
wiley   +2 more sources

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

open access: yesAdvanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham   +8 more
wiley   +1 more source

Dispersive Full-Channel Jones Matrix Modulation in Elliptical Polarization Bases via a Single-Layered Metasurface. [PDF]

open access: yesAdv Sci (Weinh)
He H   +10 more
europepmc   +1 more source

Chiral valley edge states based on Dirac mass engineering. [PDF]

open access: yesNat Commun
Liu JW   +9 more
europepmc   +1 more source

Reconfigurable spatial-mode generation and multiplexing on a scalable photonic chip. [PDF]

open access: yesNpj Nanophoton
Xiao X   +5 more
europepmc   +1 more source

Recent Advances in Stimulated Brillouin Scattering in Integrated Photonics

open access: yesAdvanced Physics Research, EarlyView.
This review systematically surveys recent advances in stimulated Brillouin scattering (SBS) within integrated photonics. It begins by elucidating the fundamental mechanisms of stimulated coupling between photons and acoustic phonons in nanoscale waveguides, enhanced by the photoelastic and moving boundary effects.
Songyue Liu   +8 more
wiley   +1 more source

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