Results 51 to 60 of about 3,876,747 (291)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Study on the Measurement Method of Indoor Elevator Noise Under the Condition of Common Wall of Elevator Shaft and Residence

Advances in Civil Engineering
Elevator noise is one of noise pollution that affect the living quality of residents. Because of the lack of accurate measurement methods and evaluation indexes for the indoor noise caused by elevator operation, the contradiction between residents ...
Junning Li, Ziming Xu, Sheng Wang, Sihong Yu, Zubin Liu   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Elevator Control Simulation Using Fuzzy Logic Management

JuTISI (Jurnal Teknik Informatika dan Sistem Informasi)
The use of a permanent magnet synchronous motor as an actuator in a ropeless elevator presents a number of difficulties that must be overcome for the system to be secure and stable.
Mehr Ali Qasimi, Asmatullah Nashir
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dynamic Analysis of High-Speed Elevator Braking Incorporating Time-Varying Slip and Multi-Mode Operational Transitions

Applied Sciences
The braking system is a critical safety mechanism for elevators, making precise performance prediction essential for robust design. However, high-speed elevator braking is a complex nonlinear dynamic process featuring real-time stick-slip transitions at ...
Zhongxu Tian, Qi Jiang, Zhiwei Gao, Can Luo   +3 more
doaj   +1 more source

The Pitch as Meaning-directing Activity: Implications for Students and Education When Fast Pace and a Striving for Novelty Set the Scene

Qualitative Studies, 2021
The elevator pitch is part of a global tendency toward homogenization of entrepreneurial content in educational programs (Fletcher, 2018), and this article shows how the pitch is naturalized as a new language because it must be decoded in order to pass ...
Nicolai Nybye
doaj   +1 more source

A lunar space elevator systems study

, 2022
Studied in this thesis are the forces acting on a tether orbiting a celestial body. This tether, coupled with autonomous climbing mechanisms, form a system called a space elevator. The feasibility of a space elevator is studied with respect to many risks,

core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Aeroservoelastic Modeling and Analysis of Aircraft with Multiple Control Surface Freeplay Nonlinearity

Aerospace
A new aeroservoelastic modeling and analysis methodology is presented for an aircraft with multiple control surface freeplay nonlinearities using the fictitious mass approach.
Utku Yurtsever, Melin Şahin, Altan Kayran   +2 more
doaj   +1 more source