Results 41 to 50 of about 185,419 (317)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The Concept of Overcoming Corruption in the Management of the Space Industry in Ukraine [PDF]
Advanced Space Law, 2018 The sixth State Space Program in Ukraine for 2018-2022. provides for the restructuring of the space industry. Its main goal is to improve the efficiency of the space industry as a whole, as well as the central office of the State Space Agency of Ukraine ...
Serhii Yuldashev
doaj +1 more source
State Regulation of the Space Industry – the Key to Effective National Security [PDF]
, 2021 Світлана Кошова, Z. Hbur
openalex +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
DEVELOPMENT OF INNOVATIVE PROCESSES IN THE COMPANIES OF SPACE INDUSTRY
Модернизация, инновация, развитие, 2016 In this article, the proposals to improve the theoretical and methodological base for the development of innovative technologies aerospace industry are made based on an analysis of its current state and the study of the factors influencing this process ...
Katrina B. Dobrova
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A critical space infrastructure perspective on Romanian national security [PDF]
Revista Română de Informatică și Automatică, 2018 Critical infrastructures are vital sociotechnical systems whose destruction or disruption would have a significant impact on the functioning of society on multiple levels.
Olga BUCOVEȚCHI +3 more
doaj