Results 61 to 70 of about 7,982,919 (309)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

A critical space infrastructure perspective on Romanian national security [PDF]

Revista Română de Informatică și Automatică, 2018
Critical infrastructures are vital sociotechnical systems whose destruction or disruption would have a significant impact on the functioning of society on multiple levels.
Olga BUCOVEȚCHI, Alexandru GEORGESCU, Marilena LAZĂR, Carmen CÎRNU   +3 more
doaj  

A 3D Non-Stationary Geometry-Based Stochastic Model for Industrial Automation Wireless Communication Systems [PDF]

arXiv, 2021
Industrial automation is one of the key application scenarios of the fifth (5G) wireless communication network. The high requirements of industrial communication systems for latency and reliability lead to the need for industrial channel models to support massive multiple-input multipleoutput (MIMO) and millimeter wave communication.
arxiv  

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Methods of business processes competitiveness increasing of the rocket and space industry enterprise

IOP Conference Series: Materials Science and Engineering, 2019
This article observes problems of the branches of the Russian defense industry complex. The short comparative analysis of scientific approaches and applied methods of management of innovative business processes of the enterprise of the rocket and space ...
A. Kukartsev, A. Boyko, V. Kukartsev, V. Tynchenko, V. Bukhtoyarov, S. V. Tynchenko   +5 more
semanticscholar   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

New Product Development Program Management Capability in Open Innovation Environment (Case Study: Space Industry) [PDF]

بهبود مدیریت, 2015
This article focused on recognizing the program management capabilities in open innovation environment. When organizations use open innovation and networks for their programs and projects, they need to acquire and promote new capabilities for managing ...
Mahdi Delavari, Mohammad Hossein Sobhiyah, Mohammad Reza Arasti, Seyed Kamal Tabaian, Tahmores Hasangholipor   +4 more
doaj  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

International projects in space and nuclear energy: Russian-Indian partnership

RUDN Journal of Public Administration, 2017
The article analyzes the influence of international projects in the development of such knowledge-intensive industries as space and nuclear energy on the Indian economy and its position in international relations.
I S Akarashov
doaj   +1 more source