Results 101 to 110 of about 30,850 (254)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

On optimal control in a nonlinear interface problem described by hemivariational inequalities

Advances in Nonlinear Analysis
This article is devoted to the existence of optimal controls in various control problems associated with a novel nonlinear interface problem on an unbounded domain with non-monotone set-valued transmission conditions.
Gwinner Joachim
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Dual-Resource Scheduling with Improved Forensic-Based Investigation Algorithm in Smart Manufacturing

Mathematics
With increasing labor costs and rapidly dynamic changes in the market demand, as well as realizing the refined management of production, more and more attention is being given to considering workers, not just machines, in the process of flexible job shop
Yuhang Zeng, Ping Lou, Jianmin Hu, Chuannian Fan, Quan Liu, Jiwei Hu   +5 more
doaj   +1 more source

Real analytic approximations which almost preserve Lipschitz constants of functions defined on the Hilbert space

, 2010
Let $X$ be a separable real Hilbert space. We show that for every Lipschitz function $f:X\rightarrow\mathbb{R}$, and for every $ε>0$, there exists a Lipschitz, real analytic function $g:X\rightarrow\mathbb{R}$ such that $|f(x)-g(x)|\leq ε$ and $\textrm{Lip}(g)\leq \textrm{Lip}(f)+ε$.
Azagra, D., Fry, R., Keener, L.
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Multiscale excitations in the diluted two-dimensional S=1/2 Heisenberg antiferromagnet

Physical Review Research
We study the excitation spectrum of the S=1/2 Heisenberg model on the randomly diluted square lattice by stochastic analytic continuation of imaginary-time correlations obtained by quantum Monte Carlo simulations in the low-temperature limit. Focusing on
Liuyun Dao, Hui Shao, Anders W. Sandvik
doaj   +1 more source