Results 121 to 130 of about 155,102 (310)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Relativistic proton fluxes observed by Van Allen Probes in the inner radiation belt during solar proton events

, 2018
On August of 2012, Van Allen Probes (VAP), also known as Radiation Belt Storm Probes (RBSP) were launched to explore the Earth’s radiation belts which are located in the inner magnetosphere. Since the Relativistic Proton Spectrometer (RPS) carried by VAP
Wang, Kaiti;Jiang, Min Fan;Tu, Hsin-I;Lai, Jen-Wei;Wu, Chien-Kuan
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The space-age presidency of John F. Kennedy a rare photographic history

, 2019
"In this engaging and inspiring work, John Bisney and J.L. Pickering have written and illustrated a thorough history of John F. Kennedy's role in developing the United States' space program.
Bisney, John 1954-, Pickering, J. L. 1957-   +1 more
core  

Soft Probes for Scanning Electrochemical Microscopy

, 2018
This chapter combines microfluidics and conventional scanning electrochemical microscopy (SECM) by developing so‐called soft probes that contain amperometric microelectrodes (MEs) and/or microfluidic channels.
Hubert H. Girault, Alexandra Bondarenko, Andreas Lesch, Fernando Cortés-Salazar, Tzu-En Lin   +4 more
core   +1 more source

Probing the Topology of the Space of Tokens with Structured Prompts

Mathematics
Some large language models (LLMs) are open source and are therefore fully open for scientific study. However, many LLMs are proprietary, and their internals are hidden, which hinders the ability of the research community to study their behavior under controlled conditions.
Michael Robinson 0001, Sourya Dey, Taisa Kushner   +2 more
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Beyond Conventional Systems: How Solid-State Batteries Empower Energy Storage and Microgrid Development in Extraterrestrial Extreme Environments

Batteries
The burgeoning commercial space sector demands next-generation energy systems that offer ultra-high specific energy, wide operational temperature ranges, intrinsic safety, and vacuum compatibility.
Yue Wang, Dakang Peng, Peng Zhang, Jianquan Liang, Shilin Yang, Hanwen An, Jiajun Wang   +6 more
doaj   +1 more source

Mapping, sensing and visualising the digital co-presence in the public arena

, 2008
This paper reports on work carried out within the Cityware project using mobile technologies to map, visualise and project the digital co-presence in the city. This paper focuses on two pilot studies exploring the Bluetooth landscape in the city of Bath.
Fatah gen. Schieck, A., O'Neill, E., Penn, A.   +2 more
core  

Interpretation of chromatographic data recovered from space missions: decoding of complex chromatograms by Fourier analysis

, 2003
In the near future, space probes will be used to investigate Titan and the P/Wirtanen comet because they are of interest for the fields of planetology and exo/astrobiology.
FELINGER A., COLL P., DONDI, Francesco, SZOPA C., VIDAL MADJAR C., NAVARRO GONZALES R., STERNBERG R., PIETROGRANDE, Maria Chiara, TELLINI I., RAULIN F.   +9 more
core   +1 more source