Results 101 to 110 of about 155,102 (310)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Doppler Orbit Determination of Deep Space Probes by the Bernese GNSS Software: First Results of the Combined Orbit Determination from DSN and Inter-Satellite Ka-Band Data from the Grail Mission [PDF]

, 2015
Navigation of deep space probes is most commonly operated using the spacecraft Doppler tracking technique. Orbital parameters are determined from a series of repeated measurements of the frequency shift of a microwave carrier over a given integration ...
Arnold, Daniel, Bertone, Stefano, Beutler, Gerhard, Mervart, Leos, Jäggi, Adrian   +4 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Fluorescent probes for imaging and detection of plant hormones and their receptors

Advanced Agrochem
Exploring plant behavior at the cellular scale in a minimally invasive manner is critical to understanding plant adaptation to the environment. Phytohormones play vital regulatory roles in multiple aspects of plant growth and development and acclimation ...
Yiliang Chen, Bo He, Mengxu Hu, Jiawei Bao, Wei Yan, Xinya Han, Yonghao Ye   +6 more
doaj   +1 more source

Evidence of Microbursts Observed Near the Equatorial Plane in the Outer Van Allen Radiation Belt

Geophysical Research Letters, 2018
We present the first evidence of electron microbursts observed near the equatorial plane in Earth's outer radiation belt. We observed the microbursts on 31 March 2017 with the Magnetic Electron Ion Spectrometer and Radiation Belt Storm Probes Ion ...
Mykhaylo Shumko, Drew L. Turner, T. P. O'Brien, Seth G. Claudepierre, John Sample, D. P. Hartley, Joseph Fennel, J. Bernard Blake, Matina Gkioulidou, Donald G. Mitchell   +9 more
doaj   +1 more source

Supersymmetric probes of wrapped M5-brane backgrounds [PDF]

, 2006
In this thesis we consider supersymmetric probes in backgrounds sourced by an M5-brane which is wrapped on holomorphic 2-cycles in C(^2) and C(^3), respectively. For the first case, we use M2-brane probes to compute the BPS spectra of the corresponding N
Loureda, José Manuel Sanchez
core  

Social interaction around a rural community photo display [PDF]

, 2009
Public displays of photographs are a common sight in community spaces, yet while much attention has been given recently to the use of digital photography in the home, the community domain remains underexplored.
Nick Taylor, Cheverst, Keith, Taylor, Nick, Keith Cheverst   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

PROBES, POPULATIONS, SAMPLES, MEASUREMENTS AND RELATIONS IN STEREOLOGY

Image Analysis and Stereology, 2011
This summary paper provides an overview of the content of stereology. The typical problem at hand centers around some three dimensional object that has an internal structure that determines its function, performance, or response.
Robert T Dehoff
doaj   +1 more source