Results 51 to 60 of about 1,294,504 (302)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Space radiation studies [PDF]

Two Active Radiation Dosimeters (ARD's) flown on Spacelab 1, performed without fault and were returned to Space Science Laboratory, MSFC for recalibration. During the flight, performance was monitored at the Huntsville Operations Center (HOSC).

core   +4 more sources

Microdosimetry Study of Proton Quality Factor Using Analytic Model Calculations

Applied Sciences, 2022
The quality factor (Q) is formally linked to the stochastic (e.g., carcinogenic) risk of diverse ionizing radiations at low doses and/or low dose rates.
Alexis Papadopoulos, Ioanna Kyriakou, Yusuke Matsuya, Sébastien Incerti, Ioannis A. Daglis, Dimitris Emfietzoglou   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Real-time dose prediction for Artemis missions

Journal of Space Weather and Space Climate
As large solar energetic particle (SEP) events can add significant radiation dose to astronauts in a short period of time and even induce acute clinical responses during missions, they present a concern for manned space flight operation.
Hu Shaowen, Barzilla Janet E., Núñez Marlon, Semones Edward   +3 more
doaj   +1 more source

Calibration of TEPC for CubeSat Experiment to Measure Space Radiation [PDF]

Journal of Astronomy and Space Sciences, 2015
A newly designed Tissue Equivalent Proportional Counter (TEPC) has been developed for the CubeSat mission, SIGMA (Scientific cubesat with Instruments for Global Magnetic field and rAdiation) to investigate space radiation.
Uk-Won Nam, Won-Kee Park, Jaejin Lee, Jeonghyun Pyo, Bong-Kon Moon, Dae-Hee Lee, Sunghwan Kim, Ho Jin, Seongwhan Lee, Jungho Kim, Hisashi Kitamura, Yukio Uchihori   +11 more
doaj   +1 more source

Displacement Damage dose and DLTS Analyses on Triple and Single Junction solar cells irradiated with electrons and protons

, 2017
Space solar cells radiation hardness is of fundamental importance in view of the future missions towards harsh radiation environment (like e.g. missions to Jupiter) and for the new spacecraft using electrical propulsion.
Baur, Carsten, Campesato, Roberta, Casale, Mariacristina, Gervasi, Massimo, Gombia, Enos, Greco, Erminio, Kingma, Aldo, Rancoita, Pier Giorgio, Rozza, Davide, Tacconi, Mauro   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparison of dose and risk estimates between ISS Partner Agencies for a 30-day lunar mission

Zeitschrift für Medizinische Physik
The International Partner Agencies of the International Space Station (ISS) present a comparison of the ionizing radiation absorbed dose and risk quantities used to characterize example missions in lunar space.
Mark R. Shavers, Edward J. Semones, Vyacheslav Shurshakov, Mikhail Dobynde, Tatsuhiko Sato, Tatsuto Komiyama, Leena Tomi, Jing Chen, Samy El-Jaby, Ulrich Straube, Chunsheng Li, Werner Rühm   +11 more
doaj   +1 more source