Results 61 to 70 of about 5,166,308 (289)

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The Impact of Space Radiation on Brains of Future Martian and Lunar Explorers

Space Weather, 2023
Astronauts will be facing many risks when they are away from Earth's environment, among which radiation is one of the most vital and troublesome issues.
Yuncong Li, Jingnan Guo, Salman Khaksarighiri, Mikhail Igorevich Dobynde, Jian Zhang, Bailiang Liu, Robert F. Wimmer‐Schweingruber   +6 more
doaj   +1 more source

Interplanetary Space Weather Effects on Lunar Reconnaissance Orbiter Avalanche Photodiode Performance [PDF]

, 2016
Space weather is a major concern for radiation-sensitive space systems, particularly for interplanetary missions, which operate outside of the protection of Earth's magnetic field. We examine and quantify the effects of space weather on silicon avalanche
Cahoy, K., Clements, E. B., Spence, H. E., Carlton, A. K., Joyce, C. J., Schwadron, N. A., Sun, X.   +6 more
core   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Validation of KREAM Based on In-Situ Measurements of Aviation Radiation in Commercial Flights

Journal of Astronomy and Space Sciences, 2020
There has been increasing necessity of more precise prediction and measurements of aviation radiation in Korea. For our air crew and passengers’ radiation safety, we develop our own radiation prediction model of KREAM.
Junga Hwang, Jaeyoung Kwak, Gyeongbok Jo, Uk-won Nam   +3 more
doaj   +1 more source

High content analysis of human fibroblast cell cultures after exposure to space radiation

, 2009
Space travel imposes risks to human health, in large part by the increased radiation levels compared to those on Earth. To understand the effects of space radiation on humans, it is important to determine the underlying cellular mechanisms. While general
Van Oostveldt, P, Meesen, G, De Meyer, T, Van Oostveldt, K, De Meyer, Tim, Baatout, Sarah, Baatout, S, Van Oostveldt, Kaat, De Vos, W, De Vos, Winnok, Meesen, Geert, Van Oostveldt, Patric, Dieriks, Birger, Ghardi, Myriam   +13 more
core   +1 more source

Non-linear optical frequency conversion crystals for space applications [PDF]

, 2011
Reliable, long term operation of high-power laser systems in the Earth orbit is not a straightforward task as the space environment entails various risks for optical surfaces and bulk materials. The increased operational risk is, among others, due to the
Mahnke, Peter, Tzeremes, Georgios, Alessandra Ciapponi, Georgios Tzeremes, Peter Mahnke, Riede, Wolfgang, Schröder, Helmut, Wolfgang Riede, Helmut Schröder, Ciapponi, Alessandra   +9 more
core   +1 more source

Genomic Loss and Epigenetic Silencing of the FOSL1 Tumor Suppressor Gene in Radiation-induced Neoplastic Transformation of Human CGL1 Cells Alters the Tumorigenic Phenotype In Vitro and In Vivo

, 2023
The CGL1 human hybrid cell system has been utilized for many decades as an excellent cellular tool for investigating neoplastic transformation. Substantial work has been done previously implicating genetic factors related to chromosome 11 to the ...
Boreham, Douglas R., Pirkkanen, Jake, Anthony J. Borgmann, Douglas R. Boreham, Christopher Thome, Gordon, Christopher, Thome, Christopher, Mendonca, Marc S., Helen Chin Sinex, Laura V. Benjamin, Marc S. Mendonca, Tharmalingam, Sujeenthar, Losch, Adam C., Jake Pirkkanen, Ryan M. Dhaemers, Christopher Gordon, Chin Sinex, Helen, Benjamin, Laura V., Borgmann, Anthony J., Dhaemers, Ryan M., Adam C. Losch, Sujeenthar Tharmalingam   +21 more
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source