Results 51 to 60 of about 46,546 (260)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Method of preliminary solution of the problem of space robot navigation by onboard astronomical measurements using the butterworth filter

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2020
A method of preliminary solution of the problem of space robot navigation based on the results of measurements carried out using its onboard optronic equipment is presented.
V. M. Ananenko, A. D. Golyakov, P. V. Kalabin   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A review on planning and control of space robots for on-orbit capture

工程科学学报
With the rapid development of space technology, space robots are playing an important role in on-orbit services, such as refueling, debris removal, and malfunctioning satellite repair.
Qian SUN, Linshuo ZHENG, Yingmin JIA
doaj   +1 more source

Gas-Driven Regolith-Sampling Strategy for Exploring Micro-Gravity Asteroids

IEEE Access, 2020
Small celestial bodies contain abundant scientific information to understand the origin and evolution of the solar system. The acquisition and analysis of regolith sample is the most direct and effective way to explore the geological construction of ...
Zeng Zhao, Shen Yin, Qichen Sun, Zhongwang Yin, Deyun Liu, Haibin Yu, Nai Zhang, Jun Li, Zhixiao Yao, Chaoyue Chao, Tao Zhang   +10 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Adaptive Neural Network-Based Fixed-Time Trajectory Tracking Control of Space Robot with Uncertainties and Input Nonlinearities

Aerospace
In this paper, a fixed-time control strategy based on neural networks is proposed for a space robot with an input dead zone. First, a model-based control method is proposed based on the fixed-time convergence framework.
Haiping Ai, Lei Jiang, An Zhu, Xiaodong Fu   +3 more
doaj   +1 more source

Hybrid Control Scheme for Grasping a Non-Cooperative Tumbling Satellite

IEEE Access, 2020
Grasping a non-cooperative “customer satellite” with a robotic arm is a challenging task for on-orbit services of spacecraft since the collision between the robot and the target is inevitable and the dynamic behaviors of the two objects are
X. F. Liu, X. Y. Zhang, P. C. Chen, G. P. Cai   +3 more
doaj   +1 more source