Results 41 to 50 of about 54,458 (280)

Impact of spaceflight and artificial gravity on sulfur metabolism in mouse liver: sulfur metabolomic and transcriptomic analysis

Scientific Reports, 2021
Spaceflight induces hepatic damage, partially owing to oxidative stress caused by the space environment such as microgravity and space radiation. We examined the roles of anti-oxidative sulfur-containing compounds on hepatic damage after spaceflight.
Ryo Kurosawa, Ryota Sugimoto, Hiroe Imai, Kohei Atsuji, Koji Yamada, Yusuke Kawano, Iwao Ohtsu, Kengo Suzuki   +7 more
doaj   +1 more source

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Science, 2019
What to expect after a year in space Space is the final frontier for understanding how extreme environments affect human physiology. Following twin astronauts, one of which spent a year-long mission on the International Space Station, Garrett-Bakelman et
Francine E. Garrett-Bakelman, Manjula Darshi, S. Green, R. Gur, Ling Lin, B. Macias, M. McKenna, Cem Meydan, Tejaswini Mishra, J. Nasrini, B. Piening, L. Rizzardi, K. Sharma, J. Siamwala, Lynn Taylor, M. Vitaterna, M. Afkarian, Ebrahim Afshinnekoo, S. Ahadi, A. Ambati, M. Arya, D. Bezdan, Colin M. Callahan, Songjie Chen, A. Choi, G. Chlipala, K. Contrepois, Marisa Covington, B. Crucian, I. De Vivo, D. Dinges, D. Ebert, Jason I. Feinberg, J. Gandara, K. George, J. Goutsias, G. Grills, A. Hargens, M. Heer, Ryan P Hillary, A. Hoofnagle, V. Hook, Garrett Jenkinson, P. Jiang, A. Keshavarzian, S. Laurie, Brittany Lee-McMullen, S. Lumpkins, M. Mackay, M. Maienschein-Cline, A. Melnick, T. Moore, K. Nakahira, H. Patel, R. Pietrzyk, Varsha Rao, Rintaro Saito, Denis Salins, Jan M. Schilling, Dorothy D. Sears, Caroline Sheridan, M. Stenger, Rakel Tryggvadottir, A. Urban, T. Vaisar, Benjamin Van Espen, Jing Zhang, M. Ziegler, S. Zwart, J. Charles, C. Kundrot, Graham B I Scott, S. Bailey, M. Basner, A. Feinberg, Stuart M. C. Lee, C. Mason, E. Mignot, B. Rana, Scott M Smith, M. Snyder, F. Turek   +81 more
semanticscholar   +1 more source

Impacts of spaceflight experience on human brain structure

bioRxiv, 2022
Spaceflight induces widespread changes in human brain morphology. It is unclear if these brain changes differ with varying mission duration or spaceflight experience history (i.e., novice or experienced, number of prior missions, time between missions ...
H. McGregor, K. Hupfeld, O. Pasternak, N. Beltran, Y. D. Dios, J. Bloomberg, S. Wood, A. Mulavara, R. Riascos, P. Reuter-Lorenz, R. Seidler   +10 more
semanticscholar   +1 more source

New Results From Galileo's First Flyby of Ganymede: Reconnection‐Driven Flows at the Low‐Latitude Magnetopause Boundary, Crossing the Cusp, and Icy Ionospheric Escape

Geophysical Research Letters, 2018
On 27 June 1996, the NASA Galileo spacecraft made humanity's first flyby of Jupiter's largest moon, Ganymede, discovering that it is the only moon known to possess an internally generated magnetic field. Resurrecting the original Galileo Plasma Subsystem
Glyn Collinson, William R. Paterson, Christopher Bard, John Dorelli, Alex Glocer, Menelaos Sarantos, Rob Wilson   +6 more
doaj   +1 more source

Changes in Optic Nerve Head and Retinal Morphology During Spaceflight and Acute Fluid Shift Reversal.

JAMA ophthalmology, 2022
Importance Countermeasures that reverse the headward fluid shift experienced in weightlessness have the potential to mitigate spaceflight-associated neuro-ocular syndrome.
Laura P. Pardon, B. Macias, Connor R. Ferguson, S. Greenwald, R. Ploutz-Snyder, I. Alferova, D. Ebert, S. Dulchavsky, A. Hargens, M. Stenger, S. Laurie   +10 more
semanticscholar   +1 more source

Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. [PDF]

, 2019
With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Agrawal, Azakie, Baio, Becker, Bergmann, Burridge, Camberos, Connor, Drosatos, Fermini, Fritsch-Yelle, Garrett-Bakelman, Gauthier, Huebsch, Hughson, Jha, Kim, Kwon, Oikonomopoulos, Perhonen, Rogers, Sharma, Sharma, Sharma, Sides, Spotnitz, Sun, Thomason, Wnorowski, Wu, Yu   +30 more
core   +1 more source

Leveraging Spaceflight to Advance Cardiovascular Research on Earth

Circulation Research, 2022
The direct (eg, radiation, microgravity) and indirect (eg, lifestyle perturbations) effects of spaceflight extend across multiple systems resulting in whole-organism cardiovascular deconditioning.
Jessica M. Scott, Jana Stoudemire, Lianne B. Dolan, Meghan Downs   +3 more
semanticscholar   +1 more source

Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice

Communications Biology, 2023
Spaceflight-related stresses impact health via various body systems, including the haematopoietic and immune systems, with effects ranging from moderate alterations of homoeostasis to serious illness.
Ritsuko Shimizu, Ikuo Hirano, Atsushi Hasegawa, Mikiko Suzuki, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Akira Uruno, Norio Suzuki, Akane Yumoto, Risa Okada, Masaki Shirakawa, Dai Shiba, Satoru Takahashi, Takafumi Suzuki, Masayuki Yamamoto   +15 more
doaj   +1 more source

Medical Implications of Space Radiation Exposure Due to Low Altitude Polar Orbits [PDF]

, 2017
Space radiation research has progressed rapidly in recent years, but there remain large uncertainties in predicting and extrapolating biological responses to humans.
Auñón-Chancellor, Serena M., Chancellor, Jeffery C., Charles, John B.   +2 more
core   +3 more sources

A review of alterations to the brain during spaceflight and the potential relevance to crew in long-duration space exploration

npj Microgravity, 2021
During spaceflight, the central nervous system (CNS) is exposed to a complex array of environmental stressors. However, the effects of long-duration spaceflight on the CNS and the resulting impact to crew health and operational performance remain largely
Meaghan Roy-O’Reilly, A. Mulavara, T. Williams   +2 more
semanticscholar   +1 more source