Results 121 to 130 of about 5,467,910 (302)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Enhancing the Electrical Uniformity and Reliability of the HfO₂-Based RRAM Using High-Permittivity Ta₂O₅ Side Wall

IEEE Journal of the Electron Devices Society, 2018
In conventional HfO2-based resistive random access memory (RRAM), SiO2 is usually adopted as side wall spacer (low-k spacer) to define the device feature size. It is found that the forming voltage of the conventional HfO2 RRAM with SiO2 spacer rises when
Mei Yuan, Yi-Ting Tseng, Po-Hsun Chen, Chih-Cheng Shih, Hui-Chun Huang, Ting-Chang Chang, Xiaole Cui, Xinnan Lin, Shengdong Zhang, Hang Zhou   +9 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

CRISPR spacer database

, 2011
This data file consists of a FASTA file containing all spacers in the CRISPR spacer database used for this publication. The name of each sequence describes the NC number of the species in which the CRISPR spacer is found, the number of the CRISPR locus ...
Rika E. Anderson (639361), Baross, John A., John A. Baross (138995), Brazelton, William J., Anderson, Rika E., William J. Brazelton (239209)   +5 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Editorial: Stereotactic body radiotherapy for prostate cancer

Frontiers in Oncology, 2022
Amar U. Kishan, Amar U. Kishan, Joseph Kaminski, Joseph Kaminski, Filippo Alongi, Filippo Alongi   +5 more
doaj   +1 more source

Sequence alignment of spacer regions.

, 2012
The spacer sequences are aligned using ClustalW2 and amino acid residues are shown in different colors. X indicates missing amino acid residues and Gaps (–) have been inserted in order to align the amino acid residues.
Zijiang Yang (112009), Yunlong Zhang (112004), Jan Johansson (112011), Gefei Chen (111998), Xiangqin Liu (112001), Anna Rising (112014), Senzhu Lin (112007), Qing Meng (112017)   +7 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Effect of inserted spacer in hepatic cell-penetrating multifunctional peptide component on the DNA intracellular delivery of quaternary complexes based on modular design

, 2016
Luchen Zhang,1 Zhenbo Li,1 Fangli Sun,2 Yuhong Xu,1 Zixiu Du1 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 2School of Engineering, Zhejiang Agriculture and Forestry University, Lin’an, Zhejiang Province, People’s Republic of
Li Z, Sun F, Zhang L, Du Z, Xu YH
core