Results 81 to 90 of about 170,575 (305)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Novel Bacteriocinogenic Lactobacillus plantarum Strains and Their Differentiation by Sequence Analysis of 16S rDNA, 16S-23S and 23S-5S Intergenic Spacer Regions and Randomly Amplified Polymorphic DNA Analysis

Food Technology and Biotechnology, 2010
Six strains of bacteriocinogenic Lactobacillus plantarum (TL1, RG11, RS5, UL4, RG14 and RI11) isolated from Malaysian foods were investigated for their structural bacteriocin genes.
Morteza Shojaei Moghadam, Thean Chor Leow, Raha Abdul Rahim, Teck Chwen Loh, Hooi Ling Foo   +4 more
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Target motifs affecting natural immunity by a constitutive CRISPR-Cas system in Escherichia coli. [PDF]

PLoS ONE, 2012
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR associated (cas) genes conform the CRISPR-Cas systems of various bacteria and archaea and produce degradation of invading nucleic acids containing sequences (protospacers) that
Cristóbal Almendros, Noemí M Guzmán, César Díez-Villaseñor, Jesús García-Martínez, Jesús García-Martínez, Francisco J M Mojica   +5 more
doaj   +1 more source

Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression [PDF]

, 2015
In a wide variety of bacterial restriction–modification systems, a regulatory `controller' protein (or C-protein) is required for effective transcription of its own gene and for transcription of the endonuclease gene found on the same operon.
Kneale, G. G., Mcgeehan, J. E., Shevtsov, M. B., Streeter, S. D., Swiderska, A., Thresh, S.-J.   +5 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Reticulation within Sporobolus: recognition of two new sections, Acinifolii and Thellungia, and a new genus, Hyalolemma (Poaceae, Chloridoideae, Zoysieae, Sporobolinae) [PDF]

PhytoKeys
We present a molecular DNA phylogeny utilizing four plastid regions (rps16–trnK spacer, rps16 intron, rpl32–trnL spacer, ndhA intron) and the nuclear ribosomal internal transcribed spacer (ITS) region, investigating 123 species of subtribe Sporobolinae ...
Paul M. Peterson, Konstantin Romaschenko, Robert J. Soreng, Yolanda Herrera Arrieta   +3 more
doaj   +3 more sources

New records of Indigofera cordifolia Heyne ex Roth. (Fabales: Fabaceae) in Saudi Arabia based on morphological and molecular evidence

Journal of Asia-Pacific Biodiversity, 2020
Indigofera cordifolia Heyne ex Roth. so far is reported only in the Arabian Peninsula from Oman. A recent field expedition in the Farasan Archipelago, Saudi Arabia, Red Sea, resulted in documentation of this species in Dumsuk Island.
Samah A. Alharbi, Rahmah N. Al-Qthanin
doaj   +1 more source

Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands. [PDF]

PLoS Genetics, 2013
In prokaryotes, clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated (Cas) proteins constitute a defence system against bacteriophages and plasmids.
Reuben B Vercoe, James T Chang, Ron L Dy, Corinda Taylor, Tamzin Gristwood, James S Clulow, Corinna Richter, Rita Przybilski, Andrew R Pitman, Peter C Fineran   +9 more
doaj   +1 more source

The size of the immune repertoire of bacteria

, 2019
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past ...
Balasubramanian, Vijay, Bradde, Serena, Goyal, Sidhartha, Nourmohammad, Armita   +3 more
core   +1 more source