Results 41 to 50 of about 166,064,242 (247)

Techniques to increase lumbar puncture success in newborn babies: the NeoCLEAR RCT

Health Technology Assessment, 2023
Background Lumbar puncture is an essential tool for diagnosing meningitis. Neonatal lumbar puncture, although frequently performed, has low success rates (50–60%).
Charles C Roehr, Andrew SJ Marshall, Alexandra Scrivens, Manish Sadarangani, Rachel Williams, Jean Yong, Louise Linsell, Virginia Chiocchia, Jennifer L Bell, Caz Stokes, Patricia Santhanadass, Ian Nicoll, Eleri Adams, Andrew King, David Murray, Ursula Bowler, Kayleigh Stanbury, Edmund Juszczak   +17 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Higher moments for random multiplicative measures [PDF]

, 2015
We obtain a condition for the Lq-convergence of martingales generated by random multiplicative cascade measures for q>1 without any self-similarity requirements on the cascades.Peer ...
Falconer, Kenneth John, K. J. Falconer
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A deep learning approach for solving a fractional order Monkeypox transmission model using a harmonic neural network optimized with SGDM

Scientific Reports
This study investigates the transmission dynamics of Monkeypox disease using a Harmonic neural network (HNN) framework optimized through stochastic gradient descent with momentum (SGDM).
Nimra Shoket, Abdul Mannan, Jamshaid Ul Rahman, Ebraheem Alzahrani, Osman Abubakar Fiidow   +4 more
doaj   +1 more source

Complex-Valued Suprametric Spaces, Related Fixed Point Results, and Their Applications to Barnsley Fern Fractal Generation and Mixed Volterra–Fredholm Integral Equations

Fractal and Fractional
The novelty of this work is that it is the first to introduce complex-valued suprametric spaces and apply it to Fractal Generation and mixed Volterra–Fredholm Integral Equations.
Sumati Kumari Panda, Velusamy Vijayakumar, Ravi P. Agarwal   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Compact embeddings of broken Sobolev spaces and applications [PDF]

, 2009
In this paper, we present several extensions of theoretical tools for the analysis of discontinuous Galerkin (DG) method beyond the linear case.
Buffa, Annalisa, Ortner, Christoph
core   +1 more source

Enhanced exploration in reinforcement learning using graph neural network based intrinsic reward mechanism

Scientific Reports
We propose a Graph Neural Network-based Intrinsic Reward Learning (GNN-IRL) framework to address the exploration–exploitation trade-off in Reinforcement Learning (RL). This approach leverages the structural modeling capabilities of Graph Neural Networks (
J. Arun Pandian, Ramkumar Thirunavukarasu, Rajganesh Nagarajan   +2 more
doaj   +1 more source