Results 101 to 110 of about 1,182,202 (280)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Standardization of spacing and weed management practices in SRI system of rice cultivation under organic conditions in relation to sustainable agriculture in the changing scenario of climate

Environment Conservation Journal, 2014
A field experiment was conducted during kharif seasons of 2009 & 2010 at Model Organic Farm of Department of Organic agriculture, CSK Himachal Pradesh Krishi Vishvavidyalya Palampur in factorial randomized block design with three replications consisting ...
Rameshwar K., J.P. Saini, Sanjay Chadha, Punam K., R.G. Upadhyay   +4 more
doaj   +1 more source

Test Spaces for Normal Spaces [PDF]

Proceedings of the American Mathematical Society, 1962
Let Q be a class of topological spaces. For X in Q, let dim X denote the dimension of X defined in terms of finite open coverings. If Q is the class of all normal spaces, then the dimension of spaces X in Q is characterized by the following theorem [2, p. 212]: dimX^n if, and only if, given any closed subset C of X, any continuous mapping of C into the
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Avaliação de produtividade de progênies de cafeeiro em dois sistemas de plantio Yield evaluation of coffee plant (Coffea arabica L.) progenies in two tillage systems

Ciência e Agrotecnologia, 2006
Objetivou-se com o presente trabalho analisar a influência do sistema de plantio (adensado e convencional) e a produtividade de cafeeiros (Coffea arabica L.), resultantes do cruzamento de Catuaí Vermelho IAC 99 com Mundo Novo IAC 379-19. Foram utilizadas
Gladyston Rodrigues Carvalho, Antônio Nazareno Guimarães Mendes, Gabriel Ferreira Bartholo, Ângela Maria Nogueira, Mário Aparecido Amaral   +4 more
doaj   +1 more source

Annular cracks in thin films of nanoparticle suspensions drying on a fiber

, 2013
We report an experimental study of the crack pattern formed during the drying of a colloidal suspension. A horizontal fiber, which provides a one dimensional, boundary-free substrate, is coated by a film of micronic thickness.
Boulogne, François, Giorgiutti-Dauphiné, Frédérique, Pauchard, Ludovic   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Time-based self-spacing techniques using cockpit display of traffic information during approach to landing in a terminal area vectoring environment [PDF]

A simulation study was undertaken to evaluate two time-based self-spacing techniques for in-trail following during terminal area approach. An electronic traffic display was provided in the weather radarscope location.
Williams, D. H.
core   +1 more source