Results 41 to 50 of about 1,517,569 (289)
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
Anales del Jardín Botánico de Madrid, 2011 Serapias perez-chiscanoi has a stable and uniform appearance with green flowers. Throughout its distribution area, however, plants have been found with deviant pink to red flowers that show similarities with other taxa that are occasionally pale flowered.
Caspar Venhuis +1 more
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Los valores y las realidades económicas
Chasqui, 2015 Algunos proyectos se han enfrentado a la tarea de enseñar a adultos las habilidades básicas con una perspectiva mucho más amplia, reconociendo explíCitamente la condición de subdesarrollo.
Peter Spain
doaj
Iperstoria, 2018 Review of the collection of essays, edited by Pilar Godayol and Annarita Taronna, about gender and translation during the Italian and Spanish totalitarian regimes.
Dora Renna
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Boletín de la Sociedad Española de Cerámica y Vidrio, 2012 Ferro Spain SA has tackled the practical viability of tile surfaces decoration by means of applying layers of reduced thickness by means of the use of digital injection technology by inkjet and, specifically, relating to effects and superficial finishes ...
Spain S.A., Ferro
doaj
Convergencia, 2020 Gender inequality, and in particular wage gender inequality, has been considered a political priority in many countries over the last decades, with the focus centered on reducing the so-called gender pay gap, i.e., looking for a mean-convergence. However,
Beatriz Larraz +2 more
doaj +1 more source