Results 51 to 60 of about 226,339 (260)
Effect of using different configurations of NSM-CFRP strips on the flexural strength of RC beams [PDF]
MATEC Web of ConferencesThe main objective of this research is to study, experimentally, the flexural strength of lightweight reinforced concrete (LWRC) beams strengthened using the near-surface mounted carbon fiber reinforced polymer technique (NSM-CFRP). Four simply supported
Katkhuda Hasan, Sahawneh Haitham
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Load test of new European record holder in span length among extradosed type bridges
E3S Web of Conferences, 2018 The article presents acceptance load tests of a newly built extradosed MS-3 bridge located along the national road DK-16 near Ostróda (Poland). The structure features significant dimension in European reference scale.
Miśkiewicz Mikołaj, Pyrzowski Łukasz
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Colour and Morphometric Variation of Donacid Bivalves from Nepa Beach, Madura Island, Indonesia
Biosaintifika: Journal of Biology & Biology Education, 2017 Donacid bivalves vary in colour, pattern, and the shape of the shells. A population of donacid bivalves had been found in the northern shore of Madura Island, Indonesia.
Reni Ambarwati, Ulfi Faizah
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A multi-season investigation of glacier surface roughness lengths through in situ and remote observation [PDF]
The Cryosphere, 2019 The roughness length values for momentum, temperature, and water vapour are key inputs to the bulk aerodynamic method for estimating turbulent heat flux.
N. Fitzpatrick, V. Radić, B. Menounos
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Study on the sag of ultra high voltage conductor with large-tonnage tension insulator string
Energy Reports, 2022 The aim of this paper is to establish a unified state equation of overhead line mechanics. An accurate calculation method of non-uniform load sag is proposed based on the simply supported beam theory. It is suitable for isolated span and continuous span.
Ruiyong Zhang +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source