Results 61 to 70 of about 233,765 (215)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Effect of practice and span length on the dual-task coordination executive test

open access: yesBrazilian Journal of Medical and Biological Research, 1999
The measure "mu", proposed as an index of the ability to coordinate concurrent box-crossing (BC) and digit-span (DS) tasks in the dual task (DT), should reflect the capacity of the executive component of the working memory system.
Sylwan R.P., Rosin F.M., Galera C.
doaj  

Simplified calculation of allowable free span length of submarine 'pipelines under action of solitary waves

open access: yesShuili Shuiyun Gongcheng Xuebao, 2017
It is important to consider the suspension of the submarine pipelines, analyzing the stability of the submarine pipelines. Because of the complex geological conditions of the seabed, the buried pipelines hung on the seabed are affected by waves.
FU Changjing, LI Guoying, ZHAO Tianlong
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

ACCURACY OF VIRTUAL INTEROCCLUSAL RECORDS FOR MULTIUNIT FIXED RESTORATIONS OF DIFFERENT SPAN LENGTH AND LOCATIONS [PDF]

open access: yesAlexandria Dental Journal
Introduction: The procedural errors associated with conventional interocclusal records (CIRs) have been mitigated by the use of intraoral scanners (IOSs) for virtual interocclusal records (VIRs).
Yousra Abdel Fatah   +2 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

Provenance variation in cone, seed and seedling characteristics in natural populations of Pinus wallichiana A.B. Jacks (Blue Pine) in India

open access: yesAnnals of Forest Research, 2011
Effects of growth hormones, rooting media and leaf size on juvenile stem cuttings of Buchholzia coriacea were investigated. Two hundred and sixteen single node cuttings were obtained from two month old seedlings of Buchholzia coriacea.
Kirti Rawat, Meena Bakshi
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

open access: yesFEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Home - About - Disclaimer - Privacy