Results 81 to 90 of about 240,872 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The influence of pre-existing vibrations on the dynamic response of medium span bridges

, 2009
Critical static bridge loading scenarios are often expressed in terms of the number of vehicles that are present on the bridge at the time of occurrence of maximum lifetime load effect.
O'Brien, Eugene J., Rattigan, Paraic, González, Arturo   +2 more
core   +1 more source

Effects of pontic span and fiber reinforcement on fracture strength of multi-unit provisional fixed partial dentures

Journal of Dental Sciences, 2019
Background/purpose: Clinically, PMMA resin is extensively used for fabricating provisional FPDs. However, fracture often occurs due to the unsatisfactory mechanical strength, especially within connectors of long-span provisional FPDs. The purpose of this
Min-Chieh Chang, Chun-Cheng Hung, Wen-Cheng Chen, Shang-Chun Tseng, Yung-Chung Chen, Jen-Chyan Wang   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

RELATIONSHIP BETWEEN SIZE AND THE RATE OF CALCIUM–DEPENDENT PROTEOLYSIS IN SKELETAL MUSCLES IN THE ATLANTIC SALMON (SALMO SALAR L.) AND BROWN TROUT (SALMO TRUTTA L.) FROM RIVERS DRAINING TO THE WHITE SEA (ARKHANGELSK REGION)

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2018
The activity level of calcium-dependent proteases of the calpain family in skeletal muscles of the atlantic salmon (Salmo salar L.) and brown trout (Salmo trutta L.) from some watercourses (the Zolotitsa River and Lopatka stream) draining to the White ...
Nadezhda Kantserova, Liudmila Lysenko, Denis Efremov, Aleksey Veselov, Nina Nemova   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Contribution of reactive and proactive control to children's working memory performance:Insight from item recall durations in response sequence planning

, 2014
The present study addressed whether developmental improvement in working memory span task performance relies upon a growing ability to proactively plan response sequences during childhood.
Jennifer Mize Nelson, Wiebe, Sandra A., Espy, Kimberly, Tiffany D. James, Sandra A. Wiebe, Kimberly Espy, Nelson, Jennifer Mize, Chevalier, Nicolas, Wiebe, Sandra A, Nicolas Chevalier, , Jennifer Mize, Nelson, James, Tiffany D., Espy, Kimberly Andrews, James, Tiffany D   +13 more
core   +1 more source

Effect of practice and span length on the dual-task coordination executive test

Brazilian Journal of Medical and Biological Research, 1999
The measure "mu", proposed as an index of the ability to coordinate concurrent box-crossing (BC) and digit-span (DS) tasks in the dual task (DT), should reflect the capacity of the executive component of the working memory system.
Sylwan R.P., Rosin F.M., Galera C.
doaj