Results 41 to 50 of about 233,765 (215)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Fatigue Life Prediction of Submarine Pipelines with Varying Span Length and Position

Journal of Marine Science and Engineering
Free spans of submarine pipelines are prone to be subjected to vortex-induced vibration (VIV) under the action of currents, leading to fatigue damage of submarine pipelines.
Daoyu Jiang, Xiaowei Huang, Deping Zhao, Haijing Yang, Guoqiang Tang   +4 more
doaj   +1 more source

Prevalence of Two-Syllable Digits Affecting Forward Digit Span Test Score

SAGE Open, 2016
The word length effect shows a connection between word length and working memory performance. Although the relationship between digit verbal length and digit span has been investigated between languages, it has not been investigated within a language. It
Lars E. Egner, Stefan Sütterlin, Ricardo G. Lugo   +2 more
doaj   +1 more source

Traffic Load Models for Latvian Road Bridges With Span Length up to 30 Meters

The Baltic Journal of Road and Bridge Engineering, 2014
Bridges are structures that propose the service life up to hundred years. However, the actual traffic load models significantly differ from the characteristic load models used in the design. The analysis of former design codes of bridges used in the last
Andris Paeglitis, Ainars Paeglitis
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Effect of using different configurations of NSM-CFRP strips on the flexural strength of RC beams [PDF]

MATEC Web of Conferences
The main objective of this research is to study, experimentally, the flexural strength of lightweight reinforced concrete (LWRC) beams strengthened using the near-surface mounted carbon fiber reinforced polymer technique (NSM-CFRP). Four simply supported
Katkhuda Hasan, Sahawneh Haitham
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Load test of new European record holder in span length among extradosed type bridges

E3S Web of Conferences, 2018
The article presents acceptance load tests of a newly built extradosed MS-3 bridge located along the national road DK-16 near Ostróda (Poland). The structure features significant dimension in European reference scale.
Miśkiewicz Mikołaj, Pyrzowski Łukasz
doaj   +1 more source