Results 41 to 50 of about 1,506,259 (311)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Tecnologías de interpretación asistida por ordenador y cognición de intérpretes: una perspectiva orientada hacia el producto y el proceso.

open access: yesRevista Tradumàtica, 2019
Hasta el momento, la investigación sobre la interpretación asistida y mediada por tecnología ha adoptado un enfoque centrado principalmente en la interpretación como producto para entender el papel de la tecnología durante esta actividad.
Christopher D. Mellinger
doaj   +1 more source

Shoreline response to sea-level rise according to equilibrium beach profiles

open access: yesScientific Reports, 2023
Shoreline position is a key parameter of a beach state, often used as a descriptor of the response of the system to changes in external forcing, such as sea-level rise.
Pau Luque   +5 more
doaj   +1 more source

Training provision and regulation: an analysis of the temporary help industry [PDF]

open access: yes, 2003
This paper studies from an economic viewpoint the juridical rationality of mandatory training provisions on Temporary Help Agencies through the Spanish Law 14/94. No positive relationship is found between the improvement in Temporary Help Agencies' added
Muñoz-Bullón, Fernando
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Automatic detection and classification of coastal Mediterranean fish from underwater images: Good practices for robust training

open access: yesFrontiers in Marine Science, 2023
Further investigation is needed to improve the identification and classification of fish in underwater images using artificial intelligence, specifically deep learning.
Ignacio A. Catalán   +12 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

The oxygen abundance in the IFU era [PDF]

open access: yes, 2012
Spatially-resolved information of gas-phase emission provided by integral field units (IFUs) are allowing us to perform a new generation of emission-line surveys, based on large samples of HII regions and full two-dimensional coverage.
Díaz, A. I.   +2 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The Interaction of Functional Predictors and the Mechanical Predictor Perseveration in a Variationist Analysis of Caribbean Spanish Heritage Speaker Subject Pronoun Expression

open access: yesLanguages, 2020
Subject pronoun expression (SPE) in Spanish has been widely studied across monolingual and bilingual varieties, showing a consistent effect of functional predictors.
Ana de Prada Pérez
doaj   +1 more source

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