Results 51 to 60 of about 13,497,395 (308)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The judicialization of territorial politics in Brazil, Colombia and Spain [PDF]

open access: yesBrazilian Political Science Review, 2013
This article explains how judicial review influences intergovernmental political dynamics in Brazil, Colombia and Spain. The argument is developed in light of two questions: how supreme courts have established themselves as pivotal institutions for ...
Helder Ferreira do Vale
doaj  

Junaci našeg doba: Lik narko-bosa u kolumbijskim telenovelama

open access: yesEtnoantropološki Problemi, 2016
U ovom radu se razmatra prikaz lika narko-bosa u kolumbijskim telenovelama. Dok zvanični diskurs tretira narko-bosa kao oličenje zla i svireposti, osobu koja podriva jedno (tobože) zdravo društveno telo, ove serije ga predstavljaju kao model socijalne ...
Diana Palaversich
doaj   +1 more source

The Interaction of Functional Predictors and the Mechanical Predictor Perseveration in a Variationist Analysis of Caribbean Spanish Heritage Speaker Subject Pronoun Expression

open access: yesLanguages, 2020
Subject pronoun expression (SPE) in Spanish has been widely studied across monolingual and bilingual varieties, showing a consistent effect of functional predictors.
Ana de Prada Pérez
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Arriving (Way Beyond) Where We Started: Forty-Eight Years of Spanish and Portuguese Historical Studies

open access: yes, 2017
This study categorizes the 3,136 papers presented at the annual meetings of the Association for Spanish and Portuguese Historical studies from 1970 through 2017 according to the following criteria: temporal focus, geographic focus, themes, and sub-themes.
Phillips, Carla Rahn
core  

Searching for a Common Place: Thoughts on Crisis, Marginality, and Social Change

open access: yesHumanities, 2017
This essay describes our neoliberal moment of crisis as a displacement of meaning regarding the more established notions of margin-center. Our times paradoxically ‘unite’ in that we are unwittingly governed by a financial logic that privileges personal ...
Txetxu Aguado, Annabel Martín
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

The Spanish Borderlands Revisited: Engaging the Public in Relating the Place of Spain in U.S. History

open access: yes, 2020
Felipe Fernández-Armesto recounts a wonderful anecdote at the start of Our America: A Hispanic History of the United States (2014). Standing before a room of young cadets at the Air Force Academy in Colorado Springs, Fernández-Armesto invited audience ...
Saenz, Charles Nicholas
core  

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