Results 51 to 60 of about 287,769 (266)

Searching for a Common Place: Thoughts on Crisis, Marginality, and Social Change

open access: yesHumanities, 2017
This essay describes our neoliberal moment of crisis as a displacement of meaning regarding the more established notions of margin-center. Our times paradoxically ‘unite’ in that we are unwittingly governed by a financial logic that privileges personal ...
Txetxu Aguado, Annabel Martín
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Underreporting Rate in Hate Crimes in Spain: Why is so High?

open access: yesAnuario de Psicología Jurídica
Hate crimes are becoming a significant criminological issue and a priority in many political agendas. One of the biggest problems is the low reporting rate to police all over countries.
Jesús Gómez   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Chilean Spanish Intonational Plateaus and Their Pragmatic Functions: A Case of Contact with Mapudungun

open access: yesLanguages
Intonational plateaus exist in Chilean Spanish in contexts in which they do not exist in any other variety of Spanish. Mapudungun, which has been in contact with Chilean Spanish for centuries, also has plateaus in similar contexts, although for years ...
Brandon M. A. Rogers, Timothy L. Face
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The Evolving Landscape of Spanish Language Representation in U.S. Media: From Overt to Covert Discrimination

open access: yesLanguages
Despite the continuously expanding presence of Spanish-speaking communities in the United States, media representation of the Spanish language and that of its speakers has remained relatively scarce.
Grace A. Parker   +2 more
doaj   +1 more source

Bridging Heterodox Views on Language and Symbols: Gilbert Durand’s Imaginaire and Mark Johnson’s Image Schemata

open access: yesGestalt Theory, 2019
This paper aims to bridge anthropological and cognitivist research undertaken by Gilbert Durand and Mark Johnson, who studied the phenomenon of meaning making in a similar way, although they had to use different terminology as their disciplines demanded.
García-Valero Benito
doaj   +1 more source

The Temporal Politics of Spiritual Conquest: History, Geography and Franciscan Orientalism in the Conquista Espiritual do Oriente of Friar Paulo da Trindade

open access: yesCulture & History Digital Journal, 2016
This article queries the relationship between imperial expansion, geographical knowledge and epistemic spatiality in Portuguese Asia. It proposes to disentangle these aspects by exploring the Conquista Espiritual do Oriente of Friar Paulo da Trindade, a ...
Zoltán Biedermann
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

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