Results 51 to 60 of about 1,498,758 (311)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga   +2 more
wiley   +1 more source

Sustainable production of osteoinductive Co 2+ , Mg 2+ and Mn 2+ -substituted apatites particles by one-pot conversion of biogenic calcium carbonate

open access: yesScientific Reports
Biogenic CaCO3 microparticles obtained from oyster shells Crassostrea gigas were used as starting material for synthesizing Co2+, Mg2+ and Mn2+-doped apatite nano-submicroparticles, through a one-step hydrothermal conversion. The conversion was completed
Sandra María Cano-Plá   +11 more
doaj   +1 more source

The judicialization of territorial politics in Brazil, Colombia and Spain [PDF]

open access: yesBrazilian Political Science Review, 2013
This article explains how judicial review influences intergovernmental political dynamics in Brazil, Colombia and Spain. The argument is developed in light of two questions: how supreme courts have established themselves as pivotal institutions for ...
Helder Ferreira do Vale
doaj  

Searching for a Common Place: Thoughts on Crisis, Marginality, and Social Change

open access: yesHumanities, 2017
This essay describes our neoliberal moment of crisis as a displacement of meaning regarding the more established notions of margin-center. Our times paradoxically ‘unite’ in that we are unwittingly governed by a financial logic that privileges personal ...
Txetxu Aguado, Annabel Martín
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Developing indicators to measure Technology Institutes` performance [PDF]

open access: yes, 2005
Technology institutes (TIs) are non-profit innovation and technology organisations aimed to encourage competitiveness of firms. They are a key organisation in the Spanish National Innovation System because of their size and closeness to the productive ...
Barge, A., Modrego, Aurelia, Núñez, R.
core   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

First-grade Latino English language learners' performance on story problems in spanish versus english [PDF]

open access: yes, 2010
To explore whether teaching English Language Learners (ELLs) with an emphasis on English story problem is appropriate, we compared the performance of a group of Latino first graders when working in Spanish and in English on two equivalent sets of story ...
Ambrose, Rebecca, Molina, Marta
core   +4 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

El espacio sujeto al tiempo en la cronística franciscana: una relectura de la "Conquista Espiritual do Oriente" de Fr. Paulo da Trindade

open access: yesCuadernos de Historia Moderna, 2014
Este artículo analiza la Conquista Espiritual do Oriente de Fr. Paulo da Trindade, obra mayor de la cronística franciscana portuguesa, escrita en Goa en la década de 1630.
Zoltán Biedermann
doaj   +1 more source

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