Results 81 to 90 of about 9,779,891 (294)

Determination of spare part consumption based on wear of friction surfaces in agricultural machinery [PDF]

open access: yesE3S Web of Conferences
This study presents a methodology for determining the consumption of spare parts (specifically gear wheels, ball bearings, roller bearings, and spline joints) used in cotton tractors operating under high-dust environmental conditions.
Irgashev Amirkul   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Optimization of Dolphin Drillings spare part management [PDF]

open access: yes, 2015
Master's thesis in Offshore technology : Industrial asset managementThe aim of this thesis is to analyze and improve Dolphin Drillings spare part management.
Wollbraaten, Maximilian
core  

Methodology of Shipboard Spare Parts Requirements Based on Whole Part Repair Strategy

open access: yesMathematics
This paper introduces an assessment method for shipboard spare parts requirements based on a whole-part repair strategy, aimed at enhancing the availability and combat effectiveness of naval equipment.
Houxiang Wang   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

An Advanced Heuristic for Multiple-Option Spare Parts Procurement after End-of-Production [PDF]

open access: yes
After-sales service is a major profit generator for more and more OEMs in industries with durable products. Successful engagement in after-sales service improves customer loyalty and allows for competitive differentiation through superior service like an
Rainer Kleber, Karl Inderfurth
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Forecasting spare part demand with installed base information

open access: yes, 2017
Service maintenance is commonly used to extend the lifetime of capital assets, such as manufacturing equipment or heavy infrastructure. When a service part, necessary to perform the maintenance action, is required but not immediately available, the ...
Syntetos, Aris   +2 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Forecasting spare part demand with installed base information: A review

open access: yes, 2017
Service maintenance is commonly used to extend the lifetime of capital assets, such as manufacturing equipment or heavy infrastructure. When a service part, necessary to perform the maintenance action, is required but not immediately available, the ...
Syntetos, Aris   +2 more
core  

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