Results 1 to 10 of about 213,065 (277)

Evaluating the effectiveness and impact of the ‘HSE Spark’ Innovation Programme: a qualitative study protocol [PDF]

BMJ Open
Introduction According to the WHO, healthcare in Europe requires ‘systemic change through innovation’ if it is to respond to the demographic, epidemiological, environmental and technological challenges the region is facing.
Michelle Howard, Linda Ryan, Jared Gormly, Threase Kessie, Caitriona Heffernan, Laney Hyland Reilly   +5 more
doaj   +2 more sources

TRANSMUT‐Spark: Transformation mutation for Apache Spark [PDF]

Software Testing, Verification and Reliability, 2022
SummaryThis paper proposesTRANSMUT‐Sparkfor automating mutation testing of big data processing code within Spark programs. Apache Spark is an engine for big data analytics/processing that hides the inherent complexity of parallel big data programming. Nonetheless, programmers must cleverly combine Spark built‐in functions within programs and guide the ...
João Batista de Souza Neto, Anamaria Martins Moreira, Genoveva Vargas‐Solar, Martin A. Musicante   +3 more
openaire   +4 more sources

Physicochemical Properties of Bis(fluorosulfonyl)amide-Based Ionic Liquids Mixed with Mg and Sr Doped Cubic Li7La3Zr2O12 Powder

Electrochemistry, 2022
Physicochemical properties of bis(fluorosulfonyl)amide anion-based ionic liquids (ILs) adsorbed on solid oxide electrolyte powder of cubic Li7La3Zr2O12 (LLZ) partially substituted by Mg and Sr were evaluated.
Yuu WATANABE, Yuki TAKEUCHI, Masato TAKI, Hidetoshi MIZUTANI, Masato IWASAKI   +4 more
doaj   +1 more source

Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood

Frontiers in Immunology, 2022
AAV gene transfer is a promising treatment for many patients with life-threatening genetic diseases. However, host immune response to the vector poses a significant challenge for the durability and safety of AAV-mediated gene therapy.
Corinne J. Smith, Nikki Ross, Ali Kamal, Kevin Y. Kim, Elizabeth Kropf, Pascal Deschatelets, Cedric Francois, William J. Quinn, Inderpal Singh, Anna Majowicz, Federico Mingozzi, Klaudia Kuranda   +11 more
doaj   +1 more source

Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates

Nature Communications, 2021
Pompe disease is currently treated with enzyme replacement therapy (ERT) with recombinant human acid alpha-glucosidase (GAA). Here, the authors show hepatic-directed gene therapy with AAV vectors enhances GAA bioavailability compared with ERT, resulting ...
Helena Costa-Verdera, Fanny Collaud, Christopher R. Riling, Pauline Sellier, Jayme M. L. Nordin, G. Michael Preston, Umut Cagin, Julien Fabregue, Simon Barral, Maryse Moya-Nilges, Jacomina Krijnse-Locker, Laetitia van Wittenberghe, Natalie Daniele, Bernard Gjata, Jeremie Cosette, Catalina Abad, Marcelo Simon-Sola, Severine Charles, Mathew Li, Marco Crosariol, Tom Antrilli, William J. Quinn, David A. Gross, Olivier Boyer, Xavier M. Anguela, Sean M. Armour, Pasqualina Colella, Giuseppe Ronzitti, Federico Mingozzi   +28 more
doaj   +1 more source

Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation

Molecular Therapy: Methods & Clinical Development, 2023
Recombinant adeno-associated viral vector (rAAV) mediated gene therapy is gaining traction in treating genetic disorders. Current rAAV production systems yield a mixture of capsids largely devoid of the transgene (empty capsid) compared with the desired ...
Ohnmar Khanal, Vijesh Kumar, Mi Jin
doaj   +1 more source

Delivering transcutaneous auricular neurostimulation (tAN) to improve symptoms associated with opioid withdrawal: results from a prospective clinical trial

Bioelectronic Medicine, 2022
Background As pharmacological treatments are the primary option for opioid use disorder, neuromodulation has recently demonstrated efficacy in managing opioid withdrawal syndrome (OWS).
Carlos F. Tirado, Stephanie N. Washburn, Alejandro Covalin, Caroline Hedenberg, Heather Vanderpool, Caroline Benner, Daniel P. Powell, Melanie A. McWade, Navid Khodaparast   +8 more
doaj   +1 more source

SPARK-X: non-parametric modeling enables scalable and robust detection of spatial expression patterns for large spatial transcriptomic studies

Genome Biology, 2021
Spatial transcriptomic studies are becoming increasingly common and large, posing important statistical and computational challenges for many analytic tasks. Here, we present SPARK-X, a non-parametric method for rapid and effective detection of spatially
Jiaqiang Zhu, Shiquan Sun, Xiang Zhou
semanticscholar   +1 more source

Spark NLP: Natural Language Understanding at Scale [PDF]

Softw. Impacts, 2021
Spark NLP is a Natural Language Processing (NLP) library built on top of Apache Spark ML. It provides simple, performant & accurate NLP annotations for machine learning pipelines that can scale easily in a distributed environment.
Veysel Kocaman, D. Talby
semanticscholar   +1 more source

Progress of Spark Plasma Sintering (SPS) Method, Systems, Ceramics Applications and Industrialization

Ceramics, 2021
The spark plasma sintering (SPS) method is of great interest to the powder and powder metallurgy industry and material researchers of academia for both product manufacturing and advanced material research and development.
M. Tokita
semanticscholar   +1 more source