Results 121 to 130 of about 513,547 (285)

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

open access: yesAdvanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan   +8 more
wiley   +1 more source

Ensemble Principal Component Analysis

open access: yesIEEE Access
Efficient representations of data are essential for processing, exploration, and human understanding, and Principal Component Analysis (PCA) is one of the most common dimensionality reduction techniques used for the analysis of large, multivariate ...
Olga Dorabiala   +2 more
doaj   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

open access: yesAdvanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen   +12 more
wiley   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

open access: yesAdvanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan   +5 more
wiley   +1 more source

Groupwise sparse PCA for spatial data

open access: yes
Many approaches for principal component analysis (PCA) with sparse entries are available. While sparsity facilitates interpretation, it also facilitates visualization of the complex result of multiple PCAs.
Filzmoser, Peter; orcid:   +2 more
core   +3 more sources

Quartic Quantum Speedups for Planted Inference

open access: yesPhysical Review X
We describe a quantum algorithm for the Planted Noisy kXOR Problem (also known as Sparse Learning Parity with Noise) that achieves a nearly quartic (fourth-power) speedup over the best known classical algorithm while using exponentially less space.
Alexander Schmidhuber   +3 more
doaj   +1 more source

Probe‐Free, Primer‐Programmed Amplicon Encoding Enables Nanopore‐Based Multiplex Detection With Deep Learning Decoding

open access: yesAdvanced Science, EarlyView.
Primer‐programmed amplicon encoding enables reporter‐probe‐free multiplex nucleic acid identification using glass nanopore sensing and deep neural network decoding. ABSTRACT Single‐reaction multiplex nucleic acid testing (NATs) must both co‐amplify multiple targets and distinguish the resulting amplicons within the product mixture.
Md. Ahasan Ahamed   +4 more
wiley   +1 more source

Decomposing the Sri Lanka Yield Curve Using Principal Component Analysis to Examine the Term Structure of the Interest Rate

open access: yesEngineering Proceedings
In this study, we delve into the dynamics of the Sri Lankan government bond market, building upon prior research that focused on the application of principal component analysis (PCA) in modelling sovereign yield curves.
K P N Sanjeewa Dayarathne   +1 more
doaj   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

open access: yesAdvanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen   +10 more
wiley   +1 more source

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