Results 81 to 90 of about 25,940 (257)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Fast Semi-Supervised Unmixing of Hyperspectral Image by Mutual Coherence Reduction and Recursive PCA

Remote Sensing, 2018
Dictionary pruning step is often employed prior to the sparse unmixing process to improve the performance of library aided unmixing. This paper presents a novel recursive PCA approach for dictionary pruning of linearly mixed hyperspectral data motivated ...
Samiran Das, Aurobinda Routray, Alok Kanti Deb   +2 more
doaj   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

Feature Extraction Based on Sparse Coding Approach for Hand Grasp Type Classification

Algorithms
The kinematics of the human hand exhibit complex and diverse characteristics unique to each individual. Various techniques such as vision-based, ultrasonic-based, and data-glove-based approaches have been employed to analyze human hand movements. However,
Jirayu Samkunta, Patinya Ketthong, Nghia Thi Mai, Md Abdus Samad Kamal, Iwanori Murakami, Kou Yamada   +5 more
doaj   +1 more source

The All-or-Nothing Phenomenon in Sparse Tensor PCA

CoRR, 2020
Corrected a typo in the statement of Theorem ...
Jonathan Niles-Weed, Ilias Zadik
openaire   +3 more sources

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Sparse Representation Based SAR Vehicle Recognition along with Aspect Angle

The Scientific World Journal, 2014
As a method of representing the test sample with few training samples from an overcomplete dictionary, sparse representation classification (SRC) has attracted much attention in synthetic aperture radar (SAR) automatic target recognition (ATR) recently ...
Xiangwei Xing, Kefeng Ji, Huanxin Zou, Jixiang Sun   +3 more
doaj   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

randPedPCA: rapid approximation of principal components from large pedigrees

Genetics Selection Evolution
Background Pedigrees continue to be extremely important in agriculture and conservation genetics, with the pedigrees of modern breeding programmes easily comprising millions of records.
Hanbin Lee, Rosalind Françoise Craddock, Gregor Gorjanc, Hannes Becher   +3 more
doaj   +1 more source