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The management of infantile spasms
Archives of Disease in Childhood, 2008Infantile spasms (IS) is the most frequent epilepsy syndrome in infancy. Although the consensus triad of spasms in clusters with hypsarrhythmia adversely affecting psychomotor development1 seems quite straightforward, the great variability of each component is a challenge not only to the clinician involved in management of the condition but also to the
Isabelle, Desguerre +2 more
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Vigabatrin for infantile spasms
Pediatric Neurology, 2002We reviewed 20 infants receiving vigabatrin for infantile spasms. Patients were not enrolled in a formal study. All families obtained the medication abroad. Age at initiation of vigabatrin ranged from 1 to 48 months; nine infants had received prior treatment with various antiepileptic medications. Patients were begun on the lowest practical dose of 125-
Wendy G, Mitchell, Namrata S, Shah
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Pediatrics, 1958
A follow-up study has been conducted on 27 patients who had infantile spasms and normal electroencephalograms before the age of 1 year, and who did not have hypsarhythmia, the electroencephalographic abnormality which is usual in this condition. The purpose of the study was to determine whether the absence of electroencephalographic abnormality alters ...
L L, BURNETT, E L, GIBBS, F A, GIBBS
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A follow-up study has been conducted on 27 patients who had infantile spasms and normal electroencephalograms before the age of 1 year, and who did not have hypsarhythmia, the electroencephalographic abnormality which is usual in this condition. The purpose of the study was to determine whether the absence of electroencephalographic abnormality alters ...
L L, BURNETT, E L, GIBBS, F A, GIBBS
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The Neurologist, 2010
Infantile spasms (West syndrome) is an epilepsy condition affecting 1 in 2000 infants. Perhaps no more worrisome neurologic disorder exists because of its frequent association with delayed development and cognition at such a young age. Despite its existence in the literature since 1841, proven therapies are limited because of efficacy, tolerability, at
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Infantile spasms (West syndrome) is an epilepsy condition affecting 1 in 2000 infants. Perhaps no more worrisome neurologic disorder exists because of its frequent association with delayed development and cognition at such a young age. Despite its existence in the literature since 1841, proven therapies are limited because of efficacy, tolerability, at
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Cochrane Database of Systematic Reviews, 2008
Infantile spasms (West's Syndrome) is a syndrome which includes a peculiar type of epileptic seizure, the spasms, and an electroencephalogram (EEG) abnormality often called hypsarrhythmia. Psychomotor retardation is frequently found at follow up. Approximately two thirds of affected infants will have a detectable underlying neurological abnormality ...
Eleanor C, Hancock +2 more
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Infantile spasms (West's Syndrome) is a syndrome which includes a peculiar type of epileptic seizure, the spasms, and an electroencephalogram (EEG) abnormality often called hypsarrhythmia. Psychomotor retardation is frequently found at follow up. Approximately two thirds of affected infants will have a detectable underlying neurological abnormality ...
Eleanor C, Hancock +2 more
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Archives of Neurology, 1976
A 6-week-old infant had recurrent contractions of the facial musculature on the left side, which continued throughout early childhood. Surgical exploration at 5 1/2 years of age revealed a ganglioneuroma of the fourth ventricle. Hemifacial spasm (HFS) in infancy and childhood suggests the possibility of serious intracranial pathologic findings.
J W, Langston, B R, Tharp
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A 6-week-old infant had recurrent contractions of the facial musculature on the left side, which continued throughout early childhood. Surgical exploration at 5 1/2 years of age revealed a ganglioneuroma of the fourth ventricle. Hemifacial spasm (HFS) in infancy and childhood suggests the possibility of serious intracranial pathologic findings.
J W, Langston, B R, Tharp
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Current Opinion in Neurology, 1995
The recent intense focus of attention on further characterization and management of infantile spasms is due, in part, to the resistant nature of these seizures and the frequently poor cognitive outcome, even when the seizures are controlled. Technological advances have increased our ability to diagnose specific brain disorders associated with infantile
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The recent intense focus of attention on further characterization and management of infantile spasms is due, in part, to the resistant nature of these seizures and the frequently poor cognitive outcome, even when the seizures are controlled. Technological advances have increased our ability to diagnose specific brain disorders associated with infantile
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Annals of Pharmacotherapy, 1994
OBJECTIVE: To summarize and evaluate the literature regarding the clinical features, epidemiology, etiology, pathophysiology, and treatment of infantile spasms. DATA SOURCES: A literature search of articles from January 1966 to July ...
S T, Haines, D T, Casto
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OBJECTIVE: To summarize and evaluate the literature regarding the clinical features, epidemiology, etiology, pathophysiology, and treatment of infantile spasms. DATA SOURCES: A literature search of articles from January 1966 to July ...
S T, Haines, D T, Casto
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Symptomatology of infantile spasms
Brain and Development, 2001Epileptic spasms in West syndrome consist of a brief phasic contraction followed by a gradually relaxing tonic component, associated with typical ictal electroencephalographic (EEG) patterns. Three different EEG patterns are associated with a clinical spasm: fast wave bursts, high voltage slow waves (HVS), and desynchronization, occurring in this order.
K, Watanabe, T, Negoro, A, Okumura
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Archives of Neurology, 2002
West syndrome is an epileptic syndrome with a devastating clinical course. In recent years, anatomic and functional neuroimaging studies have helped to diagnose the cause of the spasms in most children, but with little progress in improving the poor developmental outcome associated with this syndrome. This article cites 4 seminal observations regarding
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West syndrome is an epileptic syndrome with a devastating clinical course. In recent years, anatomic and functional neuroimaging studies have helped to diagnose the cause of the spasms in most children, but with little progress in improving the poor developmental outcome associated with this syndrome. This article cites 4 seminal observations regarding
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