Results 61 to 70 of about 132,025 (234)

Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG

Epilepsia Open
Objective Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon ...
Emmi Deckard, Rujuta Sathe, David Tabibzadeh, Aria Terango, Aran Groves, Rajsekar R. Rajaraman, Hiroki Nariai, Shaun A. Hussain   +7 more
doaj   +1 more source

X-Linked Infantile Spasms

Pediatric Neurology Briefs, 1997
Two unrelated families with X-linked infantile spasm syndrome were studied genetically by two-point and multipoint linkage analyses at the University Hospital Gasthuisberg, and Center for Human Genetics, University of Leuven, and University of Antwerp ...
J Gordon Millichap
doaj   +1 more source

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Current trends in the treatment of infantile spasms

Neuropsychiatric Disease and Treatment, 2009
Chang-Yong TsaoClinical Pediatrics and Neurology, The Ohio State University, College of Medicine, Columbus, Ohio, USAAbstract: Infantile spasms are an epilepsy syndrome with distinctive features, including age onset during infancy, characteristic ...
Chang-Yong Tsao
doaj  

Reduction of interictal epileptic burden by pulsatile corticoid therapy in children with drug‐resistant epilepsy—How stable is the effect?

Epileptic Disorders, EarlyView.
Abstract Objective The systematic use of pulsatile corticosteroid therapy (PCT) in children with drug‐resistant epilepsy has been shown to reduce epileptic activity. However, it remains unclear how long this effect will last. The objective of this study was therefore to evaluate the stability of the effect of PCT by assessing the interictal epileptic ...
Katharina Schiller, Tamir Avigdor, John Thomas, Daniel Mansilla, Chifaou Abdallah, Aline Kortas, Gabriele Unterholzner, Raluca Pana, Markus Rauchenzauner, Birgit Frauscher   +9 more
wiley   +1 more source

ILAE neuroimaging task force highlight: MRI detection of early life epilepsy caused by focal cortical dysplasia

Epileptic Disorders, EarlyView.
Abstract The ILAE Neuroimaging Task Force aims to publish educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Here, we describe a case series of three neonates with focal cortical dysplasia (FCD)‐related drug‐resistant epilepsy who underwent surgical intervention. The purpose
Nathan T. Cohen, L. Gilbert Vezina, Chima Oluigbo, Tayyba Anwar, John Archer, Boris C. Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Luis Concha, Paolo Federico, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Anna Elisabetta Vaudano, Z. Irene Wang, Shuang Wang, Gavin P. Winston, William D. Gaillard   +18 more
wiley   +1 more source

Treatment of infantile spasms

Pediatric Neurology, 1990
Although the syndrome of infantile spasms has been known for 150 years and its treatment described since 1958, controversy still surrounds the appropriate therapy for this devastating disorder. The rationale, dosage, and side effects of ACTH treatment of infantile spasms is described.
openaire   +7 more sources

A pulse rapamycin therapy for infantile spasms and associated cognitive decline

Neurobiology of Disease, 2011
Infantile spasms are seizures manifesting within a spectrum of epileptic encephalopathies of infancy that often lead to cognitive impairment. Their current therapies, including adrenocorticotropic hormone (ACTH), high dose steroids, or vigabatrin, are ...
Emmanuel Raffo, Antonietta Coppola, Tomonori Ono, Stephen W. Briggs, Aristea S. Galanopoulou   +4 more
doaj  

A pilot study on the programming protocol of vagus nerve stimulation in children with drug-resistant epilepsy: High pulse amplitude or high duty cycle. [PDF]

Epilepsia Open
Abstract Objective To compare the efficacy and safety of vagus nerve stimulation using different modes in patients with drug‐resistant epilepsy (DRE). Methods Children with DRE who underwent vagus nerve stimulator implantation between March 2019 and December 2022 were prospectively enrolled at the Peking University First Hospital.
Pan Y, Xie H, Ma J, Ji T, Liu Q, Cai L, Jiang Y, Zhang K, Zhang J, Wu Y.   +9 more
europepmc   +2 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source