Results 51 to 60 of about 5,199,774 (263)

Summing up: A functional role of eye movements along the mental number line for arithmetic

Acta Psychologica, 2022
In Western cultures, small-left and large-right spatial-numerical associations are constantly found in various simple number processing tasks. It has recently been suggested that spatial associations are also involved in more complex number processing ...
Matthias Hartmann
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Evolution and development of Spatial-Numerical Association: a comparative review

Developmental Review
Humans and animals share basic abilities to represent numerosity, called number sense, which underpins human abstract numerical skills. A key feature is Spatial-Numerical Association (SNA): the association of small numbers with the left and large ones with the right space. Initially observed in human adults using symbolic numbers, SNA has been found in
Arianna Felisatti, Martin Giurfa, Rosa Rugani   +2 more
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Spatial models for context-aware indoor navigation systems: A survey [PDF]

, 2012
This paper surveys indoor spatial models developed for research fields ranging from mobile robot mapping, to indoor location-based services (LBS), and most recently to context-aware navigation services applied to indoor environments.
Christophe Claramunt, Imad Afyouni, Christophe, Claramunt, RAY, Cyril, Cyril Ray, AFYOUNI, Imad, CLARAMUNT, Christophe   +6 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Space in Numerical and Ordinal Information: A Common Construct?

Journal of Numerical Cognition, 2017
Space is markedly involved in numerical processing, both explicitly in instrumental learning and implicitly in mental operations on numbers. Besides action decisions, action generations, and attention, the response-related effect of numerical magnitude ...
Philipp Alexander Schroeder, Hans-Christoph Nuerk, Christian Plewnia   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Magnitude or Multitude – What Counts?

Frontiers in Psychology, 2018
Recent studies revealed an association of low or high numbers (e.g., 1 vs. 9) and word semantics referring to entities typically found in upper or lower space (e.g., roof vs. root) indicating overlapping spatial representations.
Martin Lachmair, Susana Ruiz Fernández, Susana Ruiz Fernández, Susana Ruiz Fernández, Korbinian Moeller, Korbinian Moeller, Korbinian Moeller, Hans-Christoph Nuerk, Hans-Christoph Nuerk, Hans-Christoph Nuerk, Barbara Kaup, Barbara Kaup   +11 more
doaj   +1 more source