Results 71 to 80 of about 5,199,774 (263)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Full-body Movement in Numerical Trainings: A Pilot Study with an Interactive Whiteboard

International Journal of Serious Games, 2015
In this pilot study, we introduce an effective spatial-numerical training to improve children’s arithmetic abilities. We designed this training based on previous successful trainings of spatial-numerical associations (such as number line estimation) and ...
Ursula Fischer, Korbinian Moeller, Stefan Huber, Ulrike Cress, Hans-Christoph Nuerk   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

How Deep Is Your SNARC? Interactions Between Numerical Magnitude, Response Hands, and Reachability in Peripersonal Space

Frontiers in Psychology, 2018
Spatial, physical, and semantic magnitude dimensions can influence action decisions in human cognitive processing and interact with each other. For example, in the spatial-numerical associations of response code (SNARC) effect, semantic numerical ...
Johannes Lohmann, Philipp A. Schroeder, Philipp A. Schroeder, Hans-Christoph Nuerk, Hans-Christoph Nuerk, Hans-Christoph Nuerk, Christian Plewnia, Christian Plewnia, Martin V. Butz, Martin V. Butz   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

How and Why Do Number-Space Associations Co-Vary in Implicit and Explicit Magnitude Processing Tasks?

Journal of Numerical Cognition, 2017
Evidence for number-space associations in implicit and explicit magnitude processing tasks comes from the parity and magnitude SNARC effect respectively.
Carrie Georges, Danielle Hoffmann, Christine Schiltz   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Dancing with the SNARC: Measuring spatial-numerical associations on a digital dance mat.

, 2016
According to the concept of embodied numerosity, bodily experiences influence the way in which we process numerical magnitude. The development of this influence could be anchored in the spatial ordering of numbers along a mental number line ...
Class, Friderike, Nuerk, Hans-Christoph, Moeller, Korbinian, Cress, Ulrike, Huber, Stefan, Fischer, Ursula   +5 more
core   +1 more source

Spatial coding of ordinal information in short- and long-term memory

Frontiers in Human Neuroscience, 2015
The processing of numerical information induces a spatial response bias: Faster responses to small numbers with the left hand and faster responses to large numbers with the right hand.
Veronique eGinsburg, Wim eGevers
doaj   +1 more source