Results 61 to 70 of about 5,199,774 (263)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Human infants' preference for left-to-right oriented increasing numerical sequences. [PDF]
PLoS ONE, 2014 While associations between number and space, in the form of a spatially oriented numerical representation, have been extensively reported in human adults, the origins of this phenomenon are still poorly understood. The commonly accepted view is that this
Maria Dolores de Hevia +3 more
doaj +1 more source
A left-to-right bias in spatial numerical associations with dots and symbols
Abstract Number and space are intertwined in human and non-human cognition. A substantial body of research has shown that numerical magnitudes are mentally represented along a spatially oriented continuum, akin to a “mental number line”.
Eccher E +4 more
europepmc +2 more sources
On the Multitude of Mathematics Skills: Spatial-Numerical Associations and Geometry Skill?
, 2018 A commentary being part of the book edited by K.S. Mix and M. Battista.
Krzysztof Cipora +2 more
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Spatial-Numeric Associations Distort Estimates of Causal Strength. [PDF]
, 2019 When individuals provide magnitude estimates using numeric scales, they may be influenced by spatio-numeric biases.In Western, English-speaking cultures smaller magnitudes are associated with the left side of space and larger with theright. We demonstrated the impact of spatial-numeric associations on judgments of causal strength in two trial-by ...
Goedert, Kelly, Czarnowski, Daniel W.
openaire +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The role of cognitive control in the interaction of the SNARC and MARC effects
BMC PsychologyMany studies have identified two types of spatial congruency effects in number parity judgment tasks: the SNARC effect (Spatial-Numerical Association of Response Codes), related to numerical magnitude, and the MARC effect (Linguistic Markedness ...
Dandan Zhou, Yu Zhao, Kemeng Qu, Qi Chen
doaj +1 more source
The Spatial Numerical Association of Response Codes effect and math skills: why related? [PDF]
Annals of the New York Academy of Sciences, 2019 Evidence from multiple studies conducted in the past few decades converges on the conclusion that numerical properties can be associated with specific directions in space. Such Spatial-Numerical Associations (SNAs), as a signature of elementary number processing, seem to be a likely correlate of math skills.
Krzysztof Cipora +2 more
openaire +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source