Results 111 to 120 of about 6,899,247 (329)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Submicron Spatial Modulation of an Interatomic Interaction in a Bose-Einstein Condensate [PDF]
, 2010 Rekishu Yamazaki +3 more
openalex +1 more source
On proximity and hierarchy : exploring and modelling space using multilevel modelling and spatial econometrics [PDF]
, 2009 Spatial econometrics and also multilevel modelling techniques are increasingly part of the regional scientists‟ toolbox. Both approaches are used to model spatial autocorrelation in a wide variety of applications. However, it is not always clear on which
Parenti, Angela, Vanoutrive, Thomas
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways [PDF]
, 2018 Ying Yang +8 more
openalex +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Architectural interpretations of spatial form based on cellular automata with application in balneal contexts [PDF]
Arhitektura i Urbanizam, 2009 The concept of cellular automata (CA) has been challenging various disciplines for many decades. In this study the concept has been examined in the process of spatial form generation.
Petruševski Ljiljana +2 more
doaj
Inlet device with double exponential profile distributor for indoor air dispensation
Selected Scientific Papers: Journal of Civil Engineering, 2019 This paper presents a device for introducing air inside a room with the novelty of double-exponential profile of the distributor. This allows entering the rooms of large quantities of blow-in air with low velocities, with the result of possible use in ...
Domnita Florin, Kapalo Peter
doaj +1 more source
A SPATIALLY RESOLVED INNER HOLE IN THE DISK AROUND GM AURIGAE [PDF]
, 2009 A. Meredith Hughes +8 more
openalex +1 more source