Results 151 to 160 of about 1,470,342 (248)

Redefining multi-target weather forecasting with a novel deep learning model: Hierarchical temporal convolutional long short-term memory with attention (HTC-LSTM-Attn) in Bangladesh. [PDF]

PLoS One
Kabir MA, Chakma C.
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Spatially defined danger zone shapes gastric cancer progression through CCDC80⁺ fibroblast-induced CD8⁺ T cell dysfunction. [PDF]

Apoptosis
Mo S, Wang Y, Xiong R, Ma L, Xu M, Wang L, Gu W.   +6 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Overcoming missing data in spatial metabolomics with machine learning imputation to accelerate downstream discovery. [PDF]

iScience
Feng T, Wang Y, Pei S, Wang Q, Li Y, Lv J, Xia T, Chen D, Piao HL.   +8 more
europepmc   +1 more source

Spatial cognition

Annals of Physical and Rehabilitation Medicine, 2017
G. Rode, D. Pérennou, P. Azouvi
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Editorial: Spatial immunology of tissue microenvironments

Frontiers in Immunology
Roslyn A. Kemp, Felix Marsh-Wakefield, Felix Marsh-Wakefield   +2 more
doaj   +1 more source

Interrogation of imaging-based interspecies dynamics in the oral microbiome. [PDF]

J Oral Microbiol
Xiang Z, Wang Z, Ghasemi N, Wang Y, Wen J, Liu Y.   +5 more
europepmc   +1 more source