Results 101 to 110 of about 6,272,149 (253)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The research on the impact of computer games on developing children spatial ability
, 2010 [[abstract]]The purpose of this research was to explore the distinction between different gender of elementary school students on performing spatial ability and the impact of computer games on developing children spatial ability in 4th and 6th grade. The
Wu Cheng Jeam
core
Lingua Cultura, 2011 Many researchers have said that there are differences in the ways people give direction between males and females, especially in spatial task (cardinal directions, topography, mileage, building, right/left markers) (e.g., Lawton, 2001; Dabbs et al ...
Tjoo Hong Sing, Felicia Andrey Kalingga
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Using imagery to solve spatial problems
, 1998 This report focuses on the use of imagery to solve a range of spatial problems. The research projects reviewed in this report offer some insight into the range of strategies used by solvers of spatial problems and point to relationships between spatial ...
O'Driscoll-Tole, Kim +2 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Spatial Ability Improvement by Tangible Interaction
, 2018 Spatial ability is a category of human reasoning skills that plays an important role in affecting a person’s development in science, technology, engineering and mathematics.
Chun Yu +9 more
core +1 more source
Lesson Study as a Professional Development Model for Teaching Spatial Ability in Primary STEM
Education SciencesThis study explores the efficacy of a professional development (PD) model that employs lesson study to teach spatial ability skills in primary STEM education. The structure of the PD supported the ‘Insights’ mechanism by focusing on visualisation, mental
Ergi Bufasi +4 more
doaj +1 more source