Results 111 to 120 of about 755,208 (308)
Spatial ability in computer-aided design courses [PDF]
, 2014 Many studies have demonstrated that spatial ability is an important factor in the study of Industrial Engineering. Spatial ability is fundamentally important to the work of an engineer, as it is vital for project design.
Brigos Hermida, Miguel Ángel +2 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
On the independence of spatial ability from verbal ability [PDF]
, 1989 Four studies were conducted to examine three issues: (1) the relationship between spatial and verbal ability, (2) the relationship between spatial ability and social intelligence, and (3) sex differences in the relationship between spatial and verbal ...
Waggett, Jill Lynn
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Education SciencesEducational reforms increasingly require teachers to implement innovations, yet these efforts often remain unsustainable. Effective implementation is closely tied to continuous professional development and learning (CPDL).
Ergi Bufasi +4 more
doaj +1 more source
Does technical drawing increase students’ mental rotation ability?
Cogent Education, 2018 In this article, we examined whether technical drawing increased the mental rotation ability in 13- to 15-year-old students (N = 201). Students were pretested with the Mental Rotations Test. Later, a group of students was exposed to technical drawing for
Babalola Ogunkola, Carlos Knight
doaj +1 more source
Spatial Ability and STEM Achievement [PDF]
, 2020 Spatial ability encompasses a number of related skills including the ability to understand size, shape, location, and direction/distance, to reorient and navigate in space, to use maps and diagrams, to mentally transform/rotate objects and to recreate ...
Perera, Karla
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source