Results 61 to 70 of about 649,953 (265)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Informatics in Education, 2020 The purpose of this study is to investigate the effects of applications created using a web-based 3D design environment on the spatial visualisation and mental rotation abilities of secondary school students.
H. Ebru DERE, Filiz KALELIOGLU
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
ASSESSMENT AND IMPROVEMENT OF SPATIAL ABILITY DEVELOPED BY GRAPHICAL SUBJECTS
Journal of Industrial Design and Engineering Graphics, 2019 The ability to mentally manipulate 2D and 3D figures is defined as spatial visualization ability and can be measured with simple cognitive tests such as Mental Rotation Test and Mental Cutting Test.
Georgiana CORSIUC +2 more
doaj
knots geometry and its training in school [PDF]
Fanāvarī-i āmūzish, 2007 Euclidean geometry has been taught to students in schools for many years. Topological structures are among the topics that have not received much attention in school geometry.
E. Reyhani
doaj
User Experience of a 3D Interactive Human Anatomy Learning Tool
Educational Technology & Society, 2021 Embodiment is particularly relevant for learning anatomy as the knowledge to be acquired is related to the body itself. Several tools using three-dimensional (3D) anatomical structures and avatars (e.g.
Rawad Chaker +3 more
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Applied SciencesUnder emergencies such as floods and fires or during indoor navigation where cues from local landmarks and a Global Positioning System (GPS) are no longer available, the acquisition of comprehensive environmental representation becomes particularly ...
Hannah Park +2 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source