Results 41 to 50 of about 6,272,149 (253)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Study on Performance of Secondary School Students in Solving a Spatial Ability Task based on SOLO Theory [PDF]
Fanāvarī-i āmūzish, 2019 Background and Objective:Recent research by Rivera and Sinclair et al. Shows the impact of spatial abilities on achieving different goals in different fields of study and real life, and suggests the need to extend its learning to all levels of education.
S. Haghjoo, E. Reyhani
doaj +1 more source
Applied Sciences, 2021 Emerging technologies offer the potential to expand the domain of the future workforce to extreme environments, such as outer space and alien terrains.
Hannah Park +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Education Sciences, 2022 Spatial cognition involves the ability to acquire, organize, and use spatial information in the “mind’s eye.” Numerous correlational studies have demonstrated the strong relationship between spatial cognition and skill in problem-solving in mathematics ...
Sheryl Ann Sorby +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 2023 Spatial ability has been shown to have a causal relationship with students' success in science, technology, engineering, and mathematics (STEM) subjects.
Lin, Ting Jun +3 more
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Does Culture Shape Our Spatial Ability? An Investigation Based on Eye Tracking
ISPRS International Journal of Geo-Information, 2022 Culture affects people’s spatial memory, mental representations, and spatial reference frameworks. People with different cultural backgrounds show different degrees of spatial ability.
Yuyang Tian, Tianyu Yang, Weihua Dong
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source