Results 31 to 40 of about 2,266,463 (249)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

HiRes deconvolution of Spitzer infrared images [PDF]

, 2008
Spitzer provides unprecedented sensitivity in the infrared (IR), but the spatial resolution is limited by a relatively small aperture (0.85 m) of the primary mirror.
Backus, C. R., Beichman, C. A., Marsh, K. A., Thompson, T. J., Velusamy, T.   +4 more
core  

Relationship between spatial ability, visuospatial working memory and self-assessed spatial orientation ability: a study in older adults [PDF]

, 2015
This paper describes some novel spatial tasks and questionnaires designed to assess spatial and orientation abilities. The new tasks and questionnaires were administered to a sample of 90 older adults (41 males, age range 57–90), along with some other ...
A Bordin, Annalena Venneri, AS Devlin, B Milner, Bandura, C Cornoldi, CA Lawton, CA Lawton, D Voyer, DF Lohman, DH Uttal, DR Montello, E Borella, E Coluccia, E Labate, E Renzi De, EA Maguire, F Bianchini, F Pazzaglia, F Pazzaglia, F Pazzaglia, F Pazzaglia, F Pazzaglia, F Pazzaglia, Francesca Pazzaglia, G Iaria, GK Aguirre, GL Allen, GW Evans, I Viaud-Delmon, IC Mammarella, IC Mammarella, J Eliot, J Kallai, JB Carroll, K Jöreskog, KC Kirasic, KJ Bryant, KJ Bryant, KW Schaie, L Piccardi, LT Kozlowski, Lucia Ronconi, M Denis, M Hegarty, M Hegarty, M Hegarty, M Mitolo, MA Bell, MC Linn, ME Lachman, MG McGee, Micaela Mitolo, NBM Quental, NM White, P Oltman, Paolo Caffarra, R Likert, R Nori, R Nori, RB Ekstrom, S Della Sala, SG Vandenberg, Simona Gardini, T Hartley, T Wolbers, TM Sgaramella, V Ross   +67 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Use Of Cabri 3D Software As Virtual Manipulation Tool In 3-Dimension Geometry Learning To Improve Junior High School Students’ Spatial Ability [PDF]

, 2011
This study is aimed to know students’ spatial ability who work under 3-dimension learning use Cabri 3D software at Junior High School in Bandung.
Toto , Subroto
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Transition in the decay rates of stationary distributions of L\'evy motion in an energy landscape [PDF]

, 2016
The time evolution of random variables with L\'evy statistics has the ability to develop jumps, displaying very different behaviors from continuously fluctuating cases. Such patterns appear in an ever broadening range of examples including random lasers,
Kaleta, Kamil, Lőrinczi, József
core   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source