Results 131 to 140 of about 453,054 (303)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Understanding spatial inequalities and stratification in transportation accessibility to social infrastructures in South Korea: multi-dimensional planning insights

Scientific Reports
This research investigated spatial inequalities in transportation accessibility to social infrastructures (SIs) in South Korea, using a multi-dimensional methodological approach, including descriptive/bivariate analysis, explanatory factor analysis (EFA),
Sangwan Lee, Junhyuck Im, Kuk Cho
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Spatial Accessibility in Last-Mile Logistics: A New Dimension of Urban–Rural Integration

Land
Under the advancing urban–rural integration strategy, last-mile logistics, and their spatial accessibility, have become key indicators for measuring regional coordination. Focusing on Guangzhou as the case study area, this study constructs an urban–rural
Song Liu, Yongwang Cao, Qi Gao, Weitao Liu   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Street Quality Measurement and Accessibility Analysis Based on Streetscape Data: The Case of Mingcheng District in Xi’an City

Applied Sciences
As the predominant component of public space in urban areas, streets serve as a fundamental framework of a city’s spatial form. The renewal and enhancement of urban street space are integral to the broader processes of urban regeneration and the ...
Wenting Zhang, Jiajing Chen, Yixin Tian
doaj   +1 more source

Staying in school: assessing the role of access, availability and cost

, 2006
This paper investigates the role of contextual factors outside the household in determining whether or not a child attends basic education in Tajikistan.
Baschieri, Angela, Falkingham, Jane
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A comparison of floating catchment area parameters with applications to a dataset of clinics enrolled in a statewide child and adolescent psychiatric consultation program

Frontiers in Public Health
IntroductionHealthcare resources are often crucial but limited, requiring careful consideration and informed allocation based on population needs and potential healthcare access.
Jocelyn Hunyadi, Jocelyn Hunyadi, Lara S. Savas, Kehe Zhang, Kehe Zhang, Jeanette E. Deason, Ryan Ramphul, Melissa F. Peskin, Erica L. Frost, Cici Bauer, Cici Bauer   +10 more
doaj   +1 more source

The knowledge economy, hub airports and accessibility. A location based perspective. [PDF]

The airplane is gradually creating a completely new spatial pattern as did other kinds of transportation modes in the past. Successively, international airports have gone through a morphogenesis from original pure infrastructure facilities into ...
Alain Thierstein, Sven Conventz
core