Results 121 to 130 of about 137,716 (306)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
High-speed railway developments and corporate location decisions. The role of accessibility [PDF]
Accessibility is a major factor that determines the effects of transport infrastructure developments on corporate location decisions. High-speed railways have an impact on accessibility by reducing travel times and increasing comfort.
Jasper Willigers
core
ISPRS International Journal of Geo-InformationIn developing countries, aging is rapid and new towns in suburban and rural districts are emerging. However, the spatial accessibility and equity of healthcare services for older adults in new towns is rarely examined.
Mirkamiljan Mahmut +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Accessibility and the Journey to Work [PDF]
This study analyzes the effect of accessibility to jobs and houses at both the home and work ends of trips on commuting duration for respondents to a household travel survey in metropolitan Washington, DC.
David Levinson
core
Channel Scheduling for IoT Access With Spatial Correlation
IEEE Communications LettersSpatially correlated device activation is a typical feature of the Internet of Things (IoT). This motivates the development of channel scheduling (CS) methods that mitigate device collisions efficiently in such scenarios, which constitutes the scope of this work.
Prasoon Raghuwanshi +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Equity and spatial accessibility of healthcare resources in online health community network
Frontiers in PhysicsIntroduction: This study investigates the geographical distribution and fractal characteristics of the medical service network in China, using the “Good Doctor website” as a case study.Methods: Data for this study were extracted from the Good Doctor ...
Hong Gu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Location, Regional Accessibility and Price Effects: Evidence from Twin Cities Home Sales [PDF]
Regional location factors, with measures of regional accessibility foremost among them, exert a strong influence on urban property markets. While accessibility represents an important regional-scale factor, more local influences such as proximity to ...
Michael Iacono, David Levinson
core