Results 101 to 110 of about 137,716 (306)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Measuring regional cohesion effects of large-scale transport infrastructure investments - an accessibility approach [PDF]

Accessibility gains arising from transport infrastructure improvements are one of the key elements boosting a complex process involving transport, land use and regional development effects.
Elena Lopez
core  

Spatial accessibility research of public facilities considering the intensity of human activities: an analysis based on tertiary hospitals in Shenzhen, China

Open Geosciences
Evaluating and optimizing the accessibility of public facilities is a crucial task in urban planning and resource allocation. However, existing studies seldom consider the impact of human activity intensity on spatial accessibility, which leads to the ...
Bai Jielian, Dai Zhaoxin, Hu Shiruifan, Wu Pengda, Wu Zheng   +4 more
doaj   +1 more source

Exploring the Impact of Accessibility on Place Attachment in Urban Public Open Spaces: A Case Study of Jiamusi City, China

Buildings
Urban public open spaces are crucial for residents’ well-being, yet accessibility issues persist, affecting activities and social interactions. To this end, we take the main urban area of Jiamusi City, the most northeastern city in China, as an example ...
Jun Zhang, Zixuan Zhang, Yimeng Liang
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Agglomeration, accessibility and industrial location: evidence from spanish municipalities [PDF]

This paper deals with the location decisions of manufacturing firms in Spain. We analyse how agglomeration economies and transport accessibility influence the location decisions of firms at municipality level and in three industries.
Josep-Maria Arauzo-Carod, Ángel Alañón-Pardo   +1 more
core  

Transforming Public Space with Nature-Based Solutions: Lessons from Participatory Regeneration in Lorca, Spain

Land
Mediterranean cities are increasingly exposed to climate hazards, water scarcity, and social vulnerabilities, demanding integrative approaches for sustainable regeneration.
Dionysis Latinopoulos, Sara Pelaez-Sanchez, Patricia Briega Martos, Enrique Berruezo, Pablo Outón   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Potential accessibility - an interesting conceptual framework to address strategic planning issues in the Amsterdam region? [PDF]

It is difficult to prove a direct causal link between the spatial patterns of economic activities and the quality of the transport system. But it seems obvious that the transport system creates conditions, which enable economic activities to interact ...
Thomas Straatemeier
core  

Assessing Spatial Accessibility of Public and Private Residential Aged Care Facilities: A Case Study in Wuhan, Central China

ISPRS International Journal of Geo-Information, 2017
In the increasingly serious aging China, aged service is the provision of one of the most urgent and important public services to citizens, and private facilities has become an important service force with the aged service market opening in China.
Enxiang Cai, Yaolin Liu, Ying Jing, Lei Zhang, Jiwei Li, Chaohui Yin   +5 more
doaj   +1 more source